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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2008-6-20
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pubmed:abstractText |
Resistance to antiretroviral drugs remains an important limitation to successful human immunodeficiency virus type 1 (HIV-1) therapy. Resistance testing can improve treatment outcomes for infected individuals. The availability of new drugs from various classes, standardization of resistance assays, and the development of viral tropism tests necessitate new guidelines for resistance testing. The International AIDS Society-USA convened a panel of physicians and scientists with expertise in drug-resistant HIV-1, drug management, and patient care to review recently published data and presentations at scientific conferences and to provide updated recommendations. Whenever possible, resistance testing is recommended at the time of HIV infection diagnosis as part of the initial comprehensive patient assessment, as well as in all cases of virologic failure. Tropism testing is recommended whenever the use of chemokine receptor 5 antagonists is contemplated. As the roll out of antiretroviral therapy continues in developing countries, drug resistance monitoring for both subtype B and non-subtype B strains of HIV will become increasingly important.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1537-6591
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pubmed:author |
pubmed-author:Brun-VézinetFrançoiseF,
pubmed-author:ClotetBonaventuraB,
pubmed-author:GünthardHuldrych FHF,
pubmed-author:HammerScott MSM,
pubmed-author:HirschMartin SMS,
pubmed-author:JacobsenDonna MDM,
pubmed-author:JohnsonVictoria AVA,
pubmed-author:KuritzkesDaniel RDR,
pubmed-author:MellorsJohn WJW,
pubmed-author:PillayDeenanD,
pubmed-author:RichmanDouglas DDD,
pubmed-author:SchapiroJonathan MJM,
pubmed-author:YeniPatrick GPG
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
47
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
266-85
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pubmed:dateRevised |
2009-10-27
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pubmed:meshHeading |
pubmed-meshheading:18549313-Adult,
pubmed-meshheading:18549313-Anti-HIV Agents,
pubmed-meshheading:18549313-Drug Resistance, Viral,
pubmed-meshheading:18549313-Female,
pubmed-meshheading:18549313-HIV Fusion Inhibitors,
pubmed-meshheading:18549313-HIV Infections,
pubmed-meshheading:18549313-HIV-1,
pubmed-meshheading:18549313-Human Immunodeficiency Virus Proteins,
pubmed-meshheading:18549313-Humans,
pubmed-meshheading:18549313-Integrase Inhibitors,
pubmed-meshheading:18549313-Microbial Sensitivity Tests,
pubmed-meshheading:18549313-Mutation,
pubmed-meshheading:18549313-Pregnancy,
pubmed-meshheading:18549313-Protease Inhibitors,
pubmed-meshheading:18549313-Receptors, CCR5,
pubmed-meshheading:18549313-Reverse Transcriptase Inhibitors,
pubmed-meshheading:18549313-Treatment Failure,
pubmed-meshheading:18549313-Tropism
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pubmed:year |
2008
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pubmed:articleTitle |
Antiretroviral drug resistance testing in adult HIV-1 infection: 2008 recommendations of an International AIDS Society-USA panel.
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pubmed:affiliation |
Harvard Medical School, Boston, Massachusetts, USA. mshirsch@partners.org
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pubmed:publicationType |
Journal Article,
Guideline,
Research Support, Non-U.S. Gov't
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