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pubmed:abstractText |
p63 is a transcription factor required for normal epidermal development and differentiation. Because of the complexity of these processes, p63 is expected to regulate a myriad of target genes, providing impetus to many laboratories to identify these genes. p63 target genes have been shown to encode a diverse group of proteins, including structural proteins, proteins that control cell cycle withdrawal, and proteins that regulate the epidermal differentiation program. In this issue, Antonini et al., describe a novel p63 target gene whose evolutionary conservation suggests a critical role for this gene in the epidermis.
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pubmed:affiliation |
Department of Dermatology and Charles C. Gates Regenerative Medicine and Stem Cell Biology Program, University of Colorado Denver, Aurora, Colorado 80045, USA. Maranke.Koster@UCHSC.edu
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pubmed:publicationType |
Journal Article,
Comment,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, N.I.H., Extramural
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