Linked Life Data

18546471

Source:http://linkedlifedata.com/resource/pubmed/id/18546471

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2008-6-11
pubmed:abstractText
After the sequencing of the human genome, the publication of the genome of our nearest relative, the chimpanzee (Pan troglodytes) provided groundbreaking data improving the understanding of the recent human evolution. There are about forty million changes, most of them single nucleotide substitutions, which teach us about ourselves, both in terms of similarities and differences with chimpanzees. From a medical point of view differences in incidence and severity of diseases are of special importance to pinpoint novel targets and to develop innovative therapies. This analysis focuses on the cognition that chimpanzees rarely suffer from cancer. To elucidate possible reasons for this finding, we compare differences regarding apoptosis and DNA-repair on different levels of chromosome organization, gene structure, post-transcriptional and post-translational modifications to functional changes in protein structures. The result is a complex pattern of subtle variances and a few large-scale changes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0919-9454
pubmed:author
pubmed:issnType
Print
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
22-34
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
A structural genomics approach to the regulation of apoptosis: chimp vs. human.
pubmed:affiliation
Institute of Molecular Biology and Bioinformatics, Charite-University Medicine Berlin, Arnimallee 22, 14195 Berlin, Germany. jessica.ahmed@charite.de
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't