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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1991-8-28
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pubmed:abstractText |
One hundred and nine samples comprising carcinomas, adenomas, dysplastic, inflamed and normal mucosa from patients with sporadic colon cancer and ulcerative colitis (UC) were analysed for c-Ki-ras mutations. DNA was extracted from archival paraffin-embedded material, amplified using the polymerase chain reaction (PCR) and the PCR products analysed using restriction enzyme digestion. Forty-two per cent (14/33) of the sporadic carcinoma controls contained Ki-ras codon 12 mutations in contrast to 24% (8/33) of ulcerative colitis carcinomas. A significantly higher c-Ki-ras mutation rate was observed in rectal carcinomas (72%) in comparison to colonic carcinomas (28%) in control patients (P less than 0.04), while the opposite was observed in UC patients. The difference between the incidence of c-Ki-ras mutations in rectal carcinomas in UC (9%) and in sporadic rectal carcinomas (72%) was also significant (P less than 0.01). This lower prevalence rate and different site distribution of c-Ki-ras mutations in UC carcinomas compared to sporadic carcinomas suggests that specific genetic differences may underlie the causation of carcinomas arising in these situations.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1854618-13800908,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1854618-1997114,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1854618-2083852,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1854618-2187599,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1854618-2194896,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1854618-2547513,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1854618-2569552,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1854618-2649981,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1854618-2654025,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1854618-2666911,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1854618-2679847,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1854618-2841597,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1854618-2866074,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1854618-3039373,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1854618-312423,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1854618-3295155,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1854618-3318757,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1854618-3585587,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1854618-3596476,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1854618-3804020,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1854618-4847943,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1854618-5089367,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1854618-6057771,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1854618-618491,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1854618-6629368,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1854618-7297924,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1854618-7379668,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1854618-7433888,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1854618-795614
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0007-0920
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
64
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
174-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:1854618-Codon,
pubmed-meshheading:1854618-Colitis, Ulcerative,
pubmed-meshheading:1854618-Colon,
pubmed-meshheading:1854618-Colonic Neoplasms,
pubmed-meshheading:1854618-DNA, Neoplasm,
pubmed-meshheading:1854618-Genes, ras,
pubmed-meshheading:1854618-Humans,
pubmed-meshheading:1854618-Mutation,
pubmed-meshheading:1854618-Neoplasm Staging,
pubmed-meshheading:1854618-Polymerase Chain Reaction,
pubmed-meshheading:1854618-Rectal Neoplasms,
pubmed-meshheading:1854618-Restriction Mapping
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pubmed:year |
1991
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pubmed:articleTitle |
c-Ki-ras gene mutations in dysplasia and carcinomas complicating ulcerative colitis.
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pubmed:affiliation |
Department of Pathology, University of Leeds, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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