| pubmed-article:18546143 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18546143 | lifeskim:mentions | umls-concept:C0000938 | lld:lifeskim |
| pubmed-article:18546143 | lifeskim:mentions | umls-concept:C0441635 | lld:lifeskim |
| pubmed-article:18546143 | lifeskim:mentions | umls-concept:C0034790 | lld:lifeskim |
| pubmed-article:18546143 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:18546143 | lifeskim:mentions | umls-concept:C0812385 | lld:lifeskim |
| pubmed-article:18546143 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:18546143 | lifeskim:mentions | umls-concept:C1512571 | lld:lifeskim |
| pubmed-article:18546143 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:18546143 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:18546143 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:18546143 | pubmed:dateCreated | 2008-7-1 | lld:pubmed |
| pubmed-article:18546143 | pubmed:abstractText | The D gene segment expressed in both the TCR and the BCR has a challenging behavior that begs interpretation. It is incorporated in three reading frames in the rearranged transcription unit but is expressed in antigen-selected cells in a preferred frame. Why was it so important to waste 2/3 of newborn cells? The hypothesis is presented that the D region is framework playing a role in both the TCR and the BCR by determining whether a signal is transmitted to the cell upon interaction with a cognate ligand. This assumption operates in determining haplotype exclusion for the BCR and in regulating the signaling orientation for the TCR. Relevant data as well as a definitive experiment challenging the validity of this hypothesis, are discussed. | lld:pubmed |
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| pubmed-article:18546143 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18546143 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18546143 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:18546143 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18546143 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18546143 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:18546143 | pubmed:issn | 0014-2980 | lld:pubmed |
| pubmed-article:18546143 | pubmed:author | pubmed-author:CohnMelvinM | lld:pubmed |
| pubmed-article:18546143 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18546143 | pubmed:volume | 38 | lld:pubmed |
| pubmed-article:18546143 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18546143 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18546143 | pubmed:pagination | 1779-87 | lld:pubmed |
| pubmed-article:18546143 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:18546143 | pubmed:meshHeading | pubmed-meshheading:18546143... | lld:pubmed |
| pubmed-article:18546143 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18546143 | pubmed:articleTitle | A hypothesis accounting for the paradoxical expression of the D gene segment in the BCR and the TCR. | lld:pubmed |
| pubmed-article:18546143 | pubmed:affiliation | Conceptual Immunology Group, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA. cohn@salk.edu | lld:pubmed |
| pubmed-article:18546143 | pubmed:publicationType | Journal Article | lld:pubmed |
