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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2008-7-1
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pubmed:abstractText |
The D gene segment expressed in both the TCR and the BCR has a challenging behavior that begs interpretation. It is incorporated in three reading frames in the rearranged transcription unit but is expressed in antigen-selected cells in a preferred frame. Why was it so important to waste 2/3 of newborn cells? The hypothesis is presented that the D region is framework playing a role in both the TCR and the BCR by determining whether a signal is transmitted to the cell upon interaction with a cognate ligand. This assumption operates in determining haplotype exclusion for the BCR and in regulating the signaling orientation for the TCR. Relevant data as well as a definitive experiment challenging the validity of this hypothesis, are discussed.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18546143-102720,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18546143-10354368,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18546143-10933393,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18546143-11869685,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18546143-12160656,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18546143-12190919,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18546143-12496382,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18546143-12615207,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18546143-15607824,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18546143-15950737,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18546143-16139887,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18546143-16272317,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18546143-16492756,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18546143-1660812,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18546143-16754718,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18546143-17233741,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18546143-17475861,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18546143-1786075,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18546143-17889366,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18546143-18213526,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18546143-18250444,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18546143-1936114,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18546143-2017661,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18546143-2202663,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18546143-2507167,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18546143-3100050,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18546143-3263574,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18546143-3498884,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18546143-3917859,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18546143-6179669,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18546143-6769593,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18546143-6783961,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18546143-6806667,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18546143-7730622,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18546143-8112297,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18546143-81853,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18546143-8303067,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18546143-8943404,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18546143-9597140
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0014-2980
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
38
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1779-87
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:18546143-Animals,
pubmed-meshheading:18546143-Antibody Diversity,
pubmed-meshheading:18546143-Biological Evolution,
pubmed-meshheading:18546143-Gene Expression,
pubmed-meshheading:18546143-Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor,
pubmed-meshheading:18546143-Gene Rearrangement, beta-Chain T-Cell Antigen Receptor,
pubmed-meshheading:18546143-Genes, T-Cell Receptor alpha,
pubmed-meshheading:18546143-Genes, T-Cell Receptor beta,
pubmed-meshheading:18546143-Humans,
pubmed-meshheading:18546143-Immunoglobulins,
pubmed-meshheading:18546143-Reading Frames,
pubmed-meshheading:18546143-Receptors, Antigen, B-Cell,
pubmed-meshheading:18546143-Receptors, Antigen, T-Cell, alpha-beta
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pubmed:year |
2008
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pubmed:articleTitle |
A hypothesis accounting for the paradoxical expression of the D gene segment in the BCR and the TCR.
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pubmed:affiliation |
Conceptual Immunology Group, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA. cohn@salk.edu
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pubmed:publicationType |
Journal Article
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