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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
2008-6-30
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pubmed:abstractText |
CpG island (CGI) methylator phenotype (CIMP) is strongly associated with poor prognosis in neuroblastomas (NBLs; hazard ratios 7-22). Methylation of nonpromoter CGIs is useful to detect the presence of the CIMP, while the poor prognosis is considered to be caused by gene silencing due to promoter methylation. Here, promoter CGIs targeted by the CIMP were searched for.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:issn |
1423-0232
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2008 S. Karger AG, Basel.
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pubmed:issnType |
Electronic
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pubmed:volume |
74
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
50-60
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:18544995-Child,
pubmed-meshheading:18544995-Child, Preschool,
pubmed-meshheading:18544995-CpG Islands,
pubmed-meshheading:18544995-DNA Methylation,
pubmed-meshheading:18544995-Gene Silencing,
pubmed-meshheading:18544995-Genes, Neoplasm,
pubmed-meshheading:18544995-Humans,
pubmed-meshheading:18544995-Infant,
pubmed-meshheading:18544995-Infant, Newborn,
pubmed-meshheading:18544995-Neuroblastoma,
pubmed-meshheading:18544995-Phenotype,
pubmed-meshheading:18544995-Prognosis,
pubmed-meshheading:18544995-Promoter Regions, Genetic
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pubmed:year |
2008
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pubmed:articleTitle |
Identification of genes targeted by CpG island methylator phenotype in neuroblastomas, and their possible integrative involvement in poor prognosis.
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pubmed:affiliation |
Carcinogenesis Division, National Cancer Center Research Institute, Tokyo, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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