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rdf:type |
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lifeskim:mentions |
umls-concept:C0026336,
umls-concept:C0205462,
umls-concept:C0232483,
umls-concept:C0332281,
umls-concept:C0392747,
umls-concept:C0450199,
umls-concept:C0591833,
umls-concept:C1514873,
umls-concept:C1546857,
umls-concept:C1556066,
umls-concept:C1619636,
umls-concept:C2756983
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pubmed:issue |
6
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|
pubmed:dateCreated |
2008-6-11
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|
pubmed:abstractText |
The earliest response of esophageal mucosa to gastric reflux is the development of oxidative damage and inflammation. These processes contribute to the development of metaplasia known as Barrett's esophagus, as well as the progression to malignancy. Secretory phospholipase A(2) is a mediator of inflammation with levels that are increased in Barrett's metaplasia and carcinoma when compared with levels in normal samples. Our goal is to determine the role of secretory phospholipase A(2) in the development of reflux-associated changes in the esophageal mucosa.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1097-685X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
135
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1220-7
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pubmed:meshHeading |
pubmed-meshheading:18544357-Analysis of Variance,
pubmed-meshheading:18544357-Animals,
pubmed-meshheading:18544357-Barrett Esophagus,
pubmed-meshheading:18544357-Biopsy, Needle,
pubmed-meshheading:18544357-Cell Transformation, Neoplastic,
pubmed-meshheading:18544357-Disease Models, Animal,
pubmed-meshheading:18544357-Esophageal Neoplasms,
pubmed-meshheading:18544357-Fluorescent Antibody Technique,
pubmed-meshheading:18544357-Gastroesophageal Reflux,
pubmed-meshheading:18544357-Immunohistochemistry,
pubmed-meshheading:18544357-Mice,
pubmed-meshheading:18544357-Mice, Inbred BALB C,
pubmed-meshheading:18544357-Mice, Inbred C57BL,
pubmed-meshheading:18544357-Phospholipases A2,
pubmed-meshheading:18544357-Precancerous Conditions,
pubmed-meshheading:18544357-Probability,
pubmed-meshheading:18544357-Random Allocation,
pubmed-meshheading:18544357-Sensitivity and Specificity,
pubmed-meshheading:18544357-Tissue and Organ Harvesting,
pubmed-meshheading:18544357-Tumor Markers, Biological
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pubmed:year |
2008
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pubmed:articleTitle |
Secretory phospholipase A2 is required to produce histologic changes associated with gastroduodenal reflux in a murine model.
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pubmed:affiliation |
Department of Surgery, Division of Cardiothoracic Surgery, University of Colorado at Denver and Health Sciences Center, Denver, CO 80262, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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