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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2008-7-11
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pubmed:abstractText |
Pathogenic mycobacteria such as M. tuberculosis, M. bovis or M. leprae are characterised by their extremely slow growth rate which plays an important role in mycobacterial virulence and eradication of the bacteria. Various limiting factors influence the generation time of mycobacteria, and the mycobacterial DNA-binding protein 1 (MDP1) has also been implicated in growth regulation. Our strategy to investigate the role of MDP1 in mycobacterial growth consisted in the generation and characterisation of a M. bovis BCG derivative expressing a MDP1-antisense gene.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18544159-10449784,
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-2180
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
91
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:18544159-Ampicillin,
pubmed-meshheading:18544159-Animals,
pubmed-meshheading:18544159-Bacterial Proteins,
pubmed-meshheading:18544159-Cell Line,
pubmed-meshheading:18544159-DNA-Binding Proteins,
pubmed-meshheading:18544159-Gene Expression,
pubmed-meshheading:18544159-Humans,
pubmed-meshheading:18544159-Macrophages,
pubmed-meshheading:18544159-Mice,
pubmed-meshheading:18544159-Mycobacterium bovis,
pubmed-meshheading:18544159-Oligonucleotides, Antisense,
pubmed-meshheading:18544159-Oxygen,
pubmed-meshheading:18544159-Plasmids
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pubmed:year |
2008
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pubmed:articleTitle |
The mycobacterial DNA-binding protein 1 (MDP1) from Mycobacterium bovis BCG influences various growth characteristics.
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pubmed:affiliation |
Robert-Koch-Institut, Nordufer 20, 13353 Berlin, Germany. Lewina@rki.de
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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