Source:http://linkedlifedata.com/resource/pubmed/id/18543376
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
14
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| pubmed:dateCreated |
2008-6-30
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| pubmed:abstractText |
Various energy-absorbing substances, aminopyrazine (AP), 4,4'-azodianiline (ADA), and 1-chloro-4-hydroxyisoquinoline (CHIQ), together with their binary mixtures with existing acidic MALDI matrices were subjected to matrix-assisted laser desorption/ionisation mass spectrometry (MALDI-MS) and evaluated for the analysis of low molecular weight carbohydrates. The newly introduced systems, especially AP and the combination of 2,5-dihydroxybenzoic acid and aminopyrazine (DHB-AP), have solved almost all the existing problems of the generally low sensitivity of carbohydrate analysis and of the strong background noise produced from single acidic matrices. In fact, especially at a mixing ratio of 3:1 (DHB/AP), outstanding results could be achieved, enabling the detection of analytes down to a concentration of 4 fmol/microL with mass accuracy of 37 ppm. The performance of the system was finally proven by analysing dextrins and biological samples each of which showed excellent signal intensity and signal-to-noise ratio.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:status |
PubMed-not-MEDLINE
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| pubmed:month |
Jul
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| pubmed:issn |
0951-4198
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
22
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
2185-94
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| pubmed:year |
2008
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| pubmed:articleTitle |
Identification of low molecular weight carbohydrates employing new binary mixtures for matrix-assisted laser desorption/ionisation mass spectrometry.
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| pubmed:affiliation |
Institute of Analytical Chemistry and Radiochemistry, Leopold-Franzens-University Innsbruck, Innrain 52a, 6020 Innsbruck, Austria.
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| pubmed:publicationType |
Journal Article
|