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rdf:type |
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lifeskim:mentions |
umls-concept:C0011306,
umls-concept:C0019704,
umls-concept:C0185023,
umls-concept:C0205148,
umls-concept:C0237497,
umls-concept:C0597357,
umls-concept:C0907411,
umls-concept:C1314972,
umls-concept:C1521761,
umls-concept:C1539093,
umls-concept:C1551336,
umls-concept:C1704259,
umls-concept:C1705987,
umls-concept:C1880177,
umls-concept:C1947904,
umls-concept:C1999228,
umls-concept:C2825781
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pubmed:issue |
4
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pubmed:dateCreated |
2008-8-7
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pubmed:abstractText |
The dynamic interplay between dendritic cells (DCs) and human immunodeficiency virus type-1 (HIV-1) is thought to result in viral dissemination and evasion of antiviral immunity. Although initial observations suggested that the C-type lectin receptor (CLR) DC-SIGN was responsible for the trans-infection function of the virus, subsequent studies demonstrated that trans-infection of CD4(+) T cells with HIV-1 can also occur through DC-SIGN-independent mechanisms. We demonstrate that a cell surface molecule designated DCIR (for DC immunoreceptor), a member of a recently described family of DC-expressing CLRs, can participate in the capture of HIV-1 and promote infection in trans and in cis of autologous CD4(+) T cells from human immature monocyte-derived DCs. The contribution of DCIR to these processes was revealed using DCIR-specific siRNAs and a polyclonal antibody specific for the carbohydrate recognition domain of DCIR. Data from transfection experiments indicated that DCIR acts as a ligand for HIV-1 and is involved in events leading to productive virus infection. Finally, we show that the neck domain of DCIR is important for the DCIR-mediated effect on virus binding and infection. These results point to a possible role for DCIR in HIV-1 pathogenesis by supporting the productive infection of DCs and promoting virus propagation.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18541725-10438934,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18541725-10721995,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18541725-11096063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18541725-11178971,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18541725-11384997,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18541725-11588046,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18541725-11602756,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18541725-11818554,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18541725-11825572,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18541725-11994513,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18541725-12124446,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18541725-12213715,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18541725-12352970,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18541725-12502850,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/18541725-12797441,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18541725-12960229,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18541725-1352913,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/18541725-14972530,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18541725-15343375,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18541725-15481152,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18541725-15509576,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18541725-16177066,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18541725-16360206,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18541725-16413044,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18541725-16501104,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18541725-16675708,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18541725-16783855,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18541725-16817962,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18541725-17050597,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18541725-17182696,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18541725-17238285,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18541725-17312130,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18541725-17334373,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18541725-17398101,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18541725-17717529,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18541725-17728230,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18541725-17950666,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18541725-17962491,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18541725-17983270,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18541725-18040049,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18541725-18258799,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18541725-3646288,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18541725-7624395,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18541725-7629501,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18541725-9887314
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CLEC4A protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Lectins, C-Type,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Small Interfering,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Virus
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1528-0020
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
112
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1299-307
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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