18540162

Source:http://linkedlifedata.com/resource/pubmed/id/18540162

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0220781, umls-concept:C0441655, umls-concept:C1883254
pubmed:issue	5
pubmed:dateCreated	2008-6-10
pubmed:abstractText	A series of N'-nicotinoyl-3-(4'-hydroxy-3'-methylphenyl)-5-(substituted phenyl)-2-pyrazolines were synthesized by the reaction between isoniazid (INH) and chalcones and were tested for their in vitro anti-HIV activity. Among them, compound (c) showed a promising anti-HIV activity in vitro against used strains (IIIB, ROD), with IC50 of both IIIB 5.7 microM and ROD 7.0 microM.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/2985167R
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Anti-HIV Agents, http://linkedlifedata.com/resource/pubmed/chemical/Pyrazoles
pubmed:status	MEDLINE
pubmed:issn	0001-6837
pubmed:author	pubmed-author:AliMohamed AMA, pubmed-author:De ClercqErickE, pubmed-author:SiddiquiAnees AAA, pubmed-author:SriramDharmarajanD, pubmed-author:YarMohammad ShaharMS, pubmed-author:YogeeswariPerumalP
pubmed:issnType	Print
pubmed:volume	64
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	423-8
pubmed:meshHeading	pubmed-meshheading:18540162-Anti-HIV Agents, pubmed-meshheading:18540162-Cell Line, Tumor, pubmed-meshheading:18540162-Humans, pubmed-meshheading:18540162-Pyrazoles, pubmed-meshheading:18540162-Structure-Activity Relationship
pubmed:articleTitle	Synthesis and anti-HIV activity of N'-nicotinoyl--3-(4'-hydroxy-3'-methylphenyl)-5-[substituted phenyl]-2-pyrazolines.
pubmed:affiliation	Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard University, Hamdard Nagar, New Delhi, 110062, India.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't