Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2008-6-9
pubmed:abstractText
Cell differentiation requires the ability to detect and respond appropriately to a variety of extracellular signals. Here we investigate a differentiation switch induced by changes in the concentration of a single stimulus. Yeast cells exposed to high doses of mating pheromone undergo cell division arrest. Cells at intermediate doses become elongated and divide in the direction of a pheromone gradient (chemotropic growth). Either of the pheromone-responsive MAP kinases, Fus3 and Kss1, promotes cell elongation, but only Fus3 promotes chemotropic growth. Whereas Kss1 is activated rapidly and with a graded dose-response profile, Fus3 is activated slowly and exhibits a steeper dose-response relationship (ultrasensitivity). Fus3 activity requires the scaffold protein Ste5; when binding to Ste5 is abrogated, Fus3 behaves like Kss1, and the cells no longer respond to a gradient or mate efficiently with distant partners. We propose that scaffold proteins serve to modulate the temporal and dose-response behavior of the MAP kinase.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/18538663-10657304, http://linkedlifedata.com/resource/pubmed/commentcorrection/18538663-11071925, http://linkedlifedata.com/resource/pubmed/commentcorrection/18538663-11525741, http://linkedlifedata.com/resource/pubmed/commentcorrection/18538663-11571757, http://linkedlifedata.com/resource/pubmed/commentcorrection/18538663-11583629, http://linkedlifedata.com/resource/pubmed/commentcorrection/18538663-11729141, http://linkedlifedata.com/resource/pubmed/commentcorrection/18538663-1421575, http://linkedlifedata.com/resource/pubmed/commentcorrection/18538663-14734536, http://linkedlifedata.com/resource/pubmed/commentcorrection/18538663-15192700, http://linkedlifedata.com/resource/pubmed/commentcorrection/18538663-15456892, http://linkedlifedata.com/resource/pubmed/commentcorrection/18538663-15567849, http://linkedlifedata.com/resource/pubmed/commentcorrection/18538663-15713635, http://linkedlifedata.com/resource/pubmed/commentcorrection/18538663-1628831, http://linkedlifedata.com/resource/pubmed/commentcorrection/18538663-16424299, http://linkedlifedata.com/resource/pubmed/commentcorrection/18538663-17310144, http://linkedlifedata.com/resource/pubmed/commentcorrection/18538663-17952059, http://linkedlifedata.com/resource/pubmed/commentcorrection/18538663-6947258, http://linkedlifedata.com/resource/pubmed/commentcorrection/18538663-7089556, http://linkedlifedata.com/resource/pubmed/commentcorrection/18538663-7490289, http://linkedlifedata.com/resource/pubmed/commentcorrection/18538663-7490290, http://linkedlifedata.com/resource/pubmed/commentcorrection/18538663-7834738, http://linkedlifedata.com/resource/pubmed/commentcorrection/18538663-7851759, http://linkedlifedata.com/resource/pubmed/commentcorrection/18538663-8001818, http://linkedlifedata.com/resource/pubmed/commentcorrection/18538663-8062390, http://linkedlifedata.com/resource/pubmed/commentcorrection/18538663-8259520, http://linkedlifedata.com/resource/pubmed/commentcorrection/18538663-8397402, http://linkedlifedata.com/resource/pubmed/commentcorrection/18538663-9036858, http://linkedlifedata.com/resource/pubmed/commentcorrection/18538663-9363895, http://linkedlifedata.com/resource/pubmed/commentcorrection/18538663-9428768, http://linkedlifedata.com/resource/pubmed/commentcorrection/18538663-9572732
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1097-4164
pubmed:author
pubmed:issnType
Electronic
pubmed:day
6
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
649-56
pubmed:dateRevised
2011-9-26
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Regulation of cell signaling dynamics by the protein kinase-scaffold Ste5.
pubmed:affiliation
Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
pubmed:publicationType
Journal Article