Source:http://linkedlifedata.com/resource/pubmed/id/18537816
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
12
|
| pubmed:dateCreated |
2008-11-21
|
| pubmed:abstractText |
Vitiligo is an acquired pigmentary disorder and its pathogenesis remains unclear. Oxidative stress is considered to be the initial pathogenic event in the melanocyte destruction. NF-E2-related factor2 (Nrf2) is a transcription factor regulating the expression of detoxifying and antioxidant genes. To investigate the association of the Nrf2 gene promoter polymorphisms with vitiligo in Chinese Han population, the genotypes of -686A/G, -684G/A and -650C/A and the genotyping of variable number of tandem repeat were detected. The data were analysed by the chi-square test and the risk was evaluated by calculating OR and 95% CI. There was statistically significant difference in genotypic and allelic frequencies of -650C/A between the two groups (P < 0.05). A(-650) allele was significantly associated with the risk for vitiligo (OR = 1.724, chi(2) = 18.096). Polymorphism of the Nrf2 gene promoter at -650C/A was associated with the development of vitiligo and A(-650) allele may be one of the risk factors.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
1600-0625
|
| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:volume |
17
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1059-62
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| pubmed:meshHeading |
pubmed-meshheading:18537816-Adolescent,
pubmed-meshheading:18537816-Adult,
pubmed-meshheading:18537816-Age Factors,
pubmed-meshheading:18537816-Asian Continental Ancestry Group,
pubmed-meshheading:18537816-Female,
pubmed-meshheading:18537816-Gene Frequency,
pubmed-meshheading:18537816-Genetic Predisposition to Disease,
pubmed-meshheading:18537816-Genotype,
pubmed-meshheading:18537816-Humans,
pubmed-meshheading:18537816-Male,
pubmed-meshheading:18537816-Middle Aged,
pubmed-meshheading:18537816-NF-E2-Related Factor 2,
pubmed-meshheading:18537816-Odds Ratio,
pubmed-meshheading:18537816-Polymorphism, Genetic,
pubmed-meshheading:18537816-Polymorphism, Single Nucleotide,
pubmed-meshheading:18537816-Risk Factors,
pubmed-meshheading:18537816-Sex Factors,
pubmed-meshheading:18537816-Tandem Repeat Sequences,
pubmed-meshheading:18537816-Vitiligo,
pubmed-meshheading:18537816-Young Adult
|
| pubmed:year |
2008
|
| pubmed:articleTitle |
The susceptibility to vitiligo is associated with NF-E2-related factor2 (Nrf2) gene polymorphisms: a study on Chinese Han population.
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| pubmed:publicationType |
Letter
|