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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2008-6-9
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pubmed:abstractText |
Antimicrobial peptides (AMPs) are generally produced as precursor peptides containing a signal sequence, a pro-region and the mature peptide. A computational analysis of beta-defensin precursors predicts cleavage solely by signal peptidase to release the mature peptide, with no pro-region. This supports the extensive transcriptional control of beta-defensin expression compared with other AMP genes.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0929-8665
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
536-40
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pubmed:meshHeading |
pubmed-meshheading:18537746-Amino Acid Sequence,
pubmed-meshheading:18537746-Animals,
pubmed-meshheading:18537746-Computational Biology,
pubmed-meshheading:18537746-Humans,
pubmed-meshheading:18537746-Membrane Proteins,
pubmed-meshheading:18537746-Molecular Sequence Data,
pubmed-meshheading:18537746-Protein Precursors,
pubmed-meshheading:18537746-Protein Processing, Post-Translational,
pubmed-meshheading:18537746-Protein Sorting Signals,
pubmed-meshheading:18537746-Sequence Alignment,
pubmed-meshheading:18537746-Serine Endopeptidases,
pubmed-meshheading:18537746-beta-Defensins
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pubmed:year |
2008
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pubmed:articleTitle |
Computational analysis suggests beta-defensins are processed to mature peptides by signal peptidase.
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pubmed:affiliation |
Department of Oral Biology, UMDNJ-New Jersey Dental School, Newark, NJ 07101, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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