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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2008-11-21
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pubmed:abstractText |
The possibility that Ca(2+)-activated Cl(-) conductances (CaCCs) contribute to oscillations in vascular tone (vasomotion) is tested in isolated mesenteric small arteries from rats where cGMP independent (I (Cl(Ca))) and cGMP-dependent (I (Cl(Ca,cGMP))) chloride conductances are important. The effect of anion substitution and Cl(-) channel blockers on noradrenaline (NA)-stimulated tension in isometrically mounted mesenteric arteries and for chloride conductance of smooth muscle cells isolated from these arteries were assessed electrophysiologically. Cl(-) (o) replacement with aspartate blocked vasomotion while 36mM SCN(-) (o) (substituted for Cl(-)) was sufficient to inhibit vasomotion. Oscillations in tone, membrane potential, and [Ca(2+)](i) disappeared with 36mM SCN(-). DIDS and Zn(2+) blocked I (Cl(Ca,cGMP)) but not I (Cl(Ca)). Vasomotion was not sensitive to DIDS and Zn(2+), and DIDS and Zn(2+) induce vasomotion in arteries without endothelium. The vasomotion in the presence of DIDS and Zn(2+) was sensitive to 36mM SCN(-) (o). The anion substitution data indicate that Cl(-) is crucial for the V (m) and [Ca(2+)](i) oscillations underlying vasomotion. The Cl(-) channel blocker data are consistent with both CaCCs being important.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/4,4'-Diisothiocyanostilbene-2,2'-Dis...,
http://linkedlifedata.com/resource/pubmed/chemical/Aspartic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Chloride Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Chlorides,
http://linkedlifedata.com/resource/pubmed/chemical/Glycolates,
http://linkedlifedata.com/resource/pubmed/chemical/MK 473,
http://linkedlifedata.com/resource/pubmed/chemical/Niflumic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Norepinephrine,
http://linkedlifedata.com/resource/pubmed/chemical/Thiocyanates,
http://linkedlifedata.com/resource/pubmed/chemical/Vasoconstrictor Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Zinc,
http://linkedlifedata.com/resource/pubmed/chemical/thiocyanate
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0031-6768
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
457
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
389-404
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pubmed:meshHeading |
pubmed-meshheading:18536933-4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid,
pubmed-meshheading:18536933-Animals,
pubmed-meshheading:18536933-Aspartic Acid,
pubmed-meshheading:18536933-Calcium Signaling,
pubmed-meshheading:18536933-Chloride Channels,
pubmed-meshheading:18536933-Chlorides,
pubmed-meshheading:18536933-Dose-Response Relationship, Drug,
pubmed-meshheading:18536933-Glycolates,
pubmed-meshheading:18536933-Hydrogen-Ion Concentration,
pubmed-meshheading:18536933-Male,
pubmed-meshheading:18536933-Membrane Potentials,
pubmed-meshheading:18536933-Mesenteric Arteries,
pubmed-meshheading:18536933-Muscle, Smooth, Vascular,
pubmed-meshheading:18536933-Myocytes, Smooth Muscle,
pubmed-meshheading:18536933-Niflumic Acid,
pubmed-meshheading:18536933-Norepinephrine,
pubmed-meshheading:18536933-Rats,
pubmed-meshheading:18536933-Rats, Wistar,
pubmed-meshheading:18536933-Sarcoplasmic Reticulum,
pubmed-meshheading:18536933-Thiocyanates,
pubmed-meshheading:18536933-Vasoconstriction,
pubmed-meshheading:18536933-Vasoconstrictor Agents,
pubmed-meshheading:18536933-Vasodilation,
pubmed-meshheading:18536933-Zinc
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pubmed:year |
2008
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pubmed:articleTitle |
Vasomotion has chloride-dependency in rat mesenteric small arteries.
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pubmed:affiliation |
Department of Physiology, Institute of Physiology and Biophysics, University of Aarhus, Ole Worms Allé 1160, DK-8000, Aarhus C, Denmark. db@fi.au.dk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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