Linked Life Data

18536159

Source:http://linkedlifedata.com/resource/pubmed/id/18536159

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2008-6-9
pubmed:abstractText
Considering drug-induced lipid peroxidation as a possible mediator of drug-induced toxicity and exploiting the free radical scavenging action of antioxidants, the present study was designed to evaluate the protective effects of ascorbic acid (AA) and water extract of Spirulina plantesis (SP) to minimize 5-fluorouracil (5-FU)-induced lipid peroxidation. The study has been performed in vitro using goat liver as an experimental model. This evaluation was done by measuring the malondialdehyde (MDA), reduced glutathione (GSH), 4-hydroxy-2-nonenal (4-HNE) and nitric oxide (NO) content of the tissue as markers of lipid peroxidation. The results suggest that ascorbic acid and water extract of Spirulina plantesis could suppress the 5-FU-induced lipid peroxidation to a significant extent.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0001-6837
pubmed:author
pubmed:issnType
Print
pubmed:volume
64
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
335-44
pubmed:meshHeading
pubmed:articleTitle
In vitro evaluation of protective effects of ascorbic acid and water extract of Spirulina plantesis (blue green algae) on 5-fluorouracil-induced lipid peroxidation.
pubmed:affiliation
Division of Pharmaceutical Chemistry, Himalayan Pharmacy Institute, Majhitar, Rangpo, East Sikkim, 737 136, India. supratimray_in@yahoo.co.in
pubmed:publicationType
Journal Article, In Vitro