Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1976-12-23
pubmed:abstractText
The spontaneously contracting isolated rabbit ileum was used to study adenosine stimulated receptors. The inhibitory effects of adenosine were not reduced by pretreating the rabbits with either reserpine of 6-hydroxydopamine which were used to eliminate adrenergic function. Similarly the addition of tetrodotoxin to the muscle bath had no effect on the ability of adenosine to produce its inhibitory response. Of the compounds tested for agonistic activity, adenosine and ATP were the most potent (ED50 6 X 10(-7) M). The inhibition by adenosine was antagonized by both theophylline and caffeine in a surmountable manner. Theophylline analogs with charged substituents in position 7 were without antagonist activity. The results suggest that 1) receptors for adenosine or adenine nucleotides are located on the smooth muscle cells of rabbit ileum, 2) receptor stimulation requires and intact adenosine moiety and 3) methylxanthines exert their antagonistic effects by acting as competitive antagonists.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0022-3565
pubmed:author
pubmed:issnType
Print
pubmed:volume
199
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
208-15
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1976
pubmed:articleTitle
Adenosine inhibition of isolated rabbit ileum and antagonism by theophylline.
pubmed:publicationType
Journal Article, In Vitro