pubmed-article:18535625 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:18535625 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
pubmed-article:18535625 | lifeskim:mentions | umls-concept:C0013935 | lld:lifeskim |
pubmed-article:18535625 | lifeskim:mentions | umls-concept:C0043457 | lld:lifeskim |
pubmed-article:18535625 | lifeskim:mentions | umls-concept:C0242697 | lld:lifeskim |
pubmed-article:18535625 | lifeskim:mentions | umls-concept:C0920533 | lld:lifeskim |
pubmed-article:18535625 | lifeskim:mentions | umls-concept:C1521902 | lld:lifeskim |
pubmed-article:18535625 | pubmed:issue | 7 | lld:pubmed |
pubmed-article:18535625 | pubmed:dateCreated | 2008-7-1 | lld:pubmed |
pubmed-article:18535625 | pubmed:abstractText | The zebrafish u-boot (ubo) gene encodes the transcription factor Prdm1, which is essential for the specification of the primary slow-twitch muscle fibres that derive from adaxial cells. Here, we show that Prdm1 functions by acting as a transcriptional repressor and that slow-twitch-specific muscle gene expression is activated by Prdm1-mediated repression of the transcriptional repressor Sox6. Genes encoding fast-specific isoforms of sarcomeric proteins are ectopically expressed in the adaxial cells of ubo(tp39) mutant embryos. By using chromatin immunoprecipitation, we show that these are direct targets of Prdm1. Thus, Prdm1 promotes slow-twitch fibre differentiation by acting as a global repressor of fast-fibre-specific genes, as well as by abrogating the repression of slow-fibre-specific genes. | lld:pubmed |
pubmed-article:18535625 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18535625 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18535625 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18535625 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18535625 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18535625 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18535625 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18535625 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18535625 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18535625 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18535625 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18535625 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18535625 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18535625 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18535625 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18535625 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18535625 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18535625 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18535625 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18535625 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18535625 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18535625 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18535625 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18535625 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18535625 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18535625 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18535625 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18535625 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18535625 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18535625 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18535625 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18535625 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18535625 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18535625 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18535625 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18535625 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18535625 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18535625 | pubmed:language | eng | lld:pubmed |
pubmed-article:18535625 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18535625 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:18535625 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18535625 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18535625 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18535625 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18535625 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18535625 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18535625 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18535625 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18535625 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:18535625 | pubmed:month | Jul | lld:pubmed |
pubmed-article:18535625 | pubmed:issn | 1469-3178 | lld:pubmed |
pubmed-article:18535625 | pubmed:author | pubmed-author:SmithJames... | lld:pubmed |
pubmed-article:18535625 | pubmed:author | pubmed-author:ElworthyStone... | lld:pubmed |
pubmed-article:18535625 | pubmed:author | pubmed-author:InghamPhilip... | lld:pubmed |
pubmed-article:18535625 | pubmed:author | pubmed-author:WardleFiona... | lld:pubmed |
pubmed-article:18535625 | pubmed:author | pubmed-author:von... | lld:pubmed |
pubmed-article:18535625 | pubmed:author | pubmed-author:GilchristMich... | lld:pubmed |
pubmed-article:18535625 | pubmed:issnType | Electronic | lld:pubmed |
pubmed-article:18535625 | pubmed:volume | 9 | lld:pubmed |
pubmed-article:18535625 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:18535625 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:18535625 | pubmed:pagination | 683-9 | lld:pubmed |
pubmed-article:18535625 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
pubmed-article:18535625 | pubmed:meshHeading | pubmed-meshheading:18535625... | lld:pubmed |
pubmed-article:18535625 | pubmed:meshHeading | pubmed-meshheading:18535625... | lld:pubmed |
pubmed-article:18535625 | pubmed:meshHeading | pubmed-meshheading:18535625... | lld:pubmed |
pubmed-article:18535625 | pubmed:meshHeading | pubmed-meshheading:18535625... | lld:pubmed |
pubmed-article:18535625 | pubmed:meshHeading | pubmed-meshheading:18535625... | lld:pubmed |
pubmed-article:18535625 | pubmed:meshHeading | pubmed-meshheading:18535625... | lld:pubmed |
pubmed-article:18535625 | pubmed:meshHeading | pubmed-meshheading:18535625... | lld:pubmed |
pubmed-article:18535625 | pubmed:meshHeading | pubmed-meshheading:18535625... | lld:pubmed |
pubmed-article:18535625 | pubmed:meshHeading | pubmed-meshheading:18535625... | lld:pubmed |
pubmed-article:18535625 | pubmed:meshHeading | pubmed-meshheading:18535625... | lld:pubmed |
pubmed-article:18535625 | pubmed:meshHeading | pubmed-meshheading:18535625... | lld:pubmed |
pubmed-article:18535625 | pubmed:meshHeading | pubmed-meshheading:18535625... | lld:pubmed |
pubmed-article:18535625 | pubmed:meshHeading | pubmed-meshheading:18535625... | lld:pubmed |
pubmed-article:18535625 | pubmed:meshHeading | pubmed-meshheading:18535625... | lld:pubmed |
pubmed-article:18535625 | pubmed:meshHeading | pubmed-meshheading:18535625... | lld:pubmed |
pubmed-article:18535625 | pubmed:meshHeading | pubmed-meshheading:18535625... | lld:pubmed |
pubmed-article:18535625 | pubmed:meshHeading | pubmed-meshheading:18535625... | lld:pubmed |
pubmed-article:18535625 | pubmed:meshHeading | pubmed-meshheading:18535625... | lld:pubmed |
pubmed-article:18535625 | pubmed:meshHeading | pubmed-meshheading:18535625... | lld:pubmed |
pubmed-article:18535625 | pubmed:meshHeading | pubmed-meshheading:18535625... | lld:pubmed |
pubmed-article:18535625 | pubmed:meshHeading | pubmed-meshheading:18535625... | lld:pubmed |
pubmed-article:18535625 | pubmed:year | 2008 | lld:pubmed |
pubmed-article:18535625 | pubmed:articleTitle | Prdm1- and Sox6-mediated transcriptional repression specifies muscle fibre type in the zebrafish embryo. | lld:pubmed |
pubmed-article:18535625 | pubmed:affiliation | MRC Centre for Developmental and Biomedical Genetics, University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, UK. | lld:pubmed |
pubmed-article:18535625 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:18535625 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
entrez-gene:30429 | entrezgene:pubmed | pubmed-article:18535625 | lld:entrezgene |
entrez-gene:58084 | entrezgene:pubmed | pubmed-article:18535625 | lld:entrezgene |
entrez-gene:321552 | entrezgene:pubmed | pubmed-article:18535625 | lld:entrezgene |
entrez-gene:323473 | entrezgene:pubmed | pubmed-article:18535625 | lld:entrezgene |
entrez-gene:353247 | entrezgene:pubmed | pubmed-article:18535625 | lld:entrezgene |
entrez-gene:415175 | entrezgene:pubmed | pubmed-article:18535625 | lld:entrezgene |
entrez-gene:494164 | entrezgene:pubmed | pubmed-article:18535625 | lld:entrezgene |
entrez-gene:567154 | entrezgene:pubmed | pubmed-article:18535625 | lld:entrezgene |
http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:18535625 | lld:entrezgene |
http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:18535625 | lld:entrezgene |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18535625 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18535625 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18535625 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18535625 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18535625 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18535625 | lld:pubmed |