Linked Life Data

18534638

Source:http://linkedlifedata.com/resource/pubmed/id/18534638

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2008-6-30
pubmed:abstractText
The potential for chemically-regulating the acylation of natural products in whole plants has been determined by treating petunia leaves with phenylpropanoid acyl donors supplied as the respective methyl esters. Treatment with derivatives of the naturally-occurring acylating species caffeic acid resulted in a general increase in flavonol derivatives, notably caffeoylated quercetin-3-O-diglucoside (QDG) and kaempferol-3-O-diglucoside (KDG). Similarly, methyl ferulate increased the content of feruloylated KDG 40-fold. Treatment with methyl coumarate resulted in the appearance of a coumaroylated derivative of quercetin-3-O-glucuronyl-glucoside (QGGA). When the feeding studies were repeated with the equivalent phenylpropanoid isosubstituted with fluorine groups a semi-synthetic 4-fluorocinnamoyl ester of QGGA was observed. Our results demonstrate the potential to regulate the acylation of flavonols and potentially other natural products by treating whole plants with methyl esters of natural and unnatural acyl donors.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0031-9422
pubmed:author
pubmed:issnType
Print
pubmed:volume
69
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2016-21
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Modifying the acylation of flavonols in Petunia hybrida.
pubmed:affiliation
Centre for Bioactive Chemistry, Durham University, Durham, UK.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't