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rdf:type |
|
|
lifeskim:mentions |
|
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pubmed:issue |
4
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pubmed:dateCreated |
1976-12-30
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pubmed:abstractText |
Sera obtained from normal B10.BR mice were shown to inhibit selectively a specific anti-Ia alloantiserum. Partial purification of the Ia antigenic activity was accomplished by isolation of the high density lipoproteins from these sera by fractional precipitation with sodium phosphotungstate and MgCL2. Both H-2.23 and Iak antigens present in this high density lipoprotein fraction were completely adsorbed by rabbit anit-rat beta2-microglobulin immunoadsorbents, whereas specific anti-H-2.23 immunoadsorbents removed only the H-2 activity. These data deomnstrate that Ia antigens, like H-2 antigens in the sera of B10.BR mice are associated with high density lipoproteins and further suggest that both H-2 and Ia antigens are associated with a beta2-microglobulin-like molecule.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0022-1767
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
117
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1351-5
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pubmed:dateRevised |
2009-11-3
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pubmed:meshHeading |
pubmed-meshheading:185298-Animals,
pubmed-meshheading:185298-Binding, Competitive,
pubmed-meshheading:185298-Chemical Fractionation,
pubmed-meshheading:185298-Cross Reactions,
pubmed-meshheading:185298-Histocompatibility Antigens,
pubmed-meshheading:185298-Immunosorbents,
pubmed-meshheading:185298-Isoantigens,
pubmed-meshheading:185298-Lipoproteins, HDL,
pubmed-meshheading:185298-Mice,
pubmed-meshheading:185298-Mice, Inbred Strains,
pubmed-meshheading:185298-beta 2-Microglobulin
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pubmed:year |
1976
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pubmed:articleTitle |
Characterization of Ia antigens in mouse serum.
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|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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