Source:http://linkedlifedata.com/resource/pubmed/id/18528747
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
2009-3-2
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pubmed:abstractText |
To determine whether portal plasma flow (PPF) and net portal appearance of amino acids (AA) could be affected by 2-hydroxy-4-methylthiobutyrate (HMB), six barrows (35-day-old, 8.6+/-1.4 kg), implanted with arterial, portal and mesenteric catheters, were fed a DL-methionine (as the control) or HMB-supplemented diet once hourly and infused intramesenterically with 1% p-amino hippurate. PPF was numerically 9% higher (P=0.09) in HMB-fed pigs than in controls over a 4-6 h period. Compared with controls, pigs fed the HMB diet had increased (P<0.05) net portal balance and/or appearance of leucine, isoleucine, histidine, arginine and alanine, but had decreased (P<0.05) portal appearance of glutamate over a 6-h period. The concentration of acetate in the lumen of the distal small intestine was higher (P=0.01) in HMB-fed pigs than in controls (25.14 vs. 7.64 mmol/kg). mRNA levels for proglucagon and endothelial nitric-oxide synthase (eNOS) in stomach and proximal small intestine, and mRNA levels for GLP-2 receptor (GLP-2R) in stomach were higher (P<0.05) in HMB-fed pigs compared with those in controls. Collectively, HMB supplementation increased concentrations of short-chain fatty acids in intestinal lumen, expression of proglucagon, GLP-2R, and eNOS genes, and net portal absorption of AA. These novel findings from the study with pigs may also have important implications for intestinal nutrition and health in humans.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Amino Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Fatty Acids,
http://linkedlifedata.com/resource/pubmed/chemical/GLP-2 receptor,
http://linkedlifedata.com/resource/pubmed/chemical/Methionine,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type III,
http://linkedlifedata.com/resource/pubmed/chemical/Proglucagon,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Glucagon,
http://linkedlifedata.com/resource/pubmed/chemical/alpha-hydroxy-gamma-methylmercaptobu...
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1438-2199
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pubmed:author | |
pubmed:issnType |
Electronic
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pubmed:volume |
36
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
501-9
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pubmed:meshHeading |
pubmed-meshheading:18528747-Amino Acids,
pubmed-meshheading:18528747-Animals,
pubmed-meshheading:18528747-Diet,
pubmed-meshheading:18528747-Fatty Acids,
pubmed-meshheading:18528747-Intestines,
pubmed-meshheading:18528747-Methionine,
pubmed-meshheading:18528747-Nitric Oxide Synthase Type III,
pubmed-meshheading:18528747-Portal System,
pubmed-meshheading:18528747-Proglucagon,
pubmed-meshheading:18528747-RNA, Messenger,
pubmed-meshheading:18528747-Receptors, Glucagon,
pubmed-meshheading:18528747-Regional Blood Flow,
pubmed-meshheading:18528747-Swine
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pubmed:year |
2009
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pubmed:articleTitle |
Effects of 2-hydroxy-4-methylthiobutyrate on portal plasma flow and net portal appearance of amino acids in piglets.
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pubmed:affiliation |
Department of Animal Nutrition, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, People's Republic of China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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