Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2008-6-5
pubmed:abstractText
It is widely accepted that there is marked inter-individual variation in platelet function, although this has not been formally studied in large numbers of subjects. We have recruited and studied three large populations: one to characterize platelet variation and the factors responsible for it; a second to estimate heritabilities of the variation in platelet function; and a third to test for interactions between platelet genes and hormone therapy in postmenopausal women. We find that platelet variability is substantial, inherited and can be reproducibly detected. We genotyped 2145 women in the Heart and Estrogen/progestin Replacement Study followed for coronary heart disease (CHD) events for 6 years and found that common combinations of polymorphisms in the genes for GPIbalpha and GPVI were associated with hormone therapy harm, benefit or no effect. If corroborated in future studies, platelet genotyping could be used to predict postmenopausal hormone safety.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/18528467-10758948, http://linkedlifedata.com/resource/pubmed/commentcorrection/18528467-12090862, http://linkedlifedata.com/resource/pubmed/commentcorrection/18528467-12117397, http://linkedlifedata.com/resource/pubmed/commentcorrection/18528467-12411949, http://linkedlifedata.com/resource/pubmed/commentcorrection/18528467-12904517, http://linkedlifedata.com/resource/pubmed/commentcorrection/18528467-15082697, http://linkedlifedata.com/resource/pubmed/commentcorrection/18528467-15972447, http://linkedlifedata.com/resource/pubmed/commentcorrection/18528467-16022956, http://linkedlifedata.com/resource/pubmed/commentcorrection/18528467-1967954, http://linkedlifedata.com/resource/pubmed/commentcorrection/18528467-2336086, http://linkedlifedata.com/resource/pubmed/commentcorrection/18528467-3531859, http://linkedlifedata.com/resource/pubmed/commentcorrection/18528467-7878622, http://linkedlifedata.com/resource/pubmed/commentcorrection/18528467-9718051
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0065-7778
pubmed:author
pubmed:issnType
Print
pubmed:volume
117
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
103-11; discussion 111-2
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Platelet reactivity and genetics down on the pharm.
pubmed:affiliation
Thrombosis Research Section, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA. pbray@bcm.tmc.edu
pubmed:publicationType
Journal Article, In Vitro, Research Support, N.I.H., Extramural