Linked Life Data

18528286

Source:http://linkedlifedata.com/resource/pubmed/id/18528286

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2008-6-26
pubmed:abstractText
Fibroblast growth factor receptor 3 (FGFR3) protein is aberrantly expressed in approximately 15% of cases of plasma cell myeloma as a result of t(4;14)(p16.3;q32), and FGFR3 expression in myeloma is associated with an adverse prognosis. Novel, recently developed therapeutic agents that target the FGFR3 pathway are currently in clinical trials for myeloma. Although extensively studied in plasma cell neoplasms, there is little information in the literature regarding FGFR3 expression in malignant lymphomas, and it is unclear whether lymphoma patients may also benefit from anti-FGFR3 therapy. We, therefore, examined the expression of FGFR3 by immunohistochemistry in 70 cases of malignant lymphoma using tissue microarrays and whole paraffin sections. Of 22 cases of plasma cell myeloma analyzed as controls, FGFR3 positivity was seen in 3/5 t(4;14) positive cases (60%) and in none of 17 t(4;14) negative cases (P=0.006). Weak-to-moderate cytoplasmic FGFR3 staining was seen in 6/43 (12%) B-cell non-Hodgkin lymphomas and 2/17 (12%) T-cell lymphomas, with staining observed at low incidence in many histologic types. Cytoplasmic staining was also seen infrequently in classic Hodgkin lymphoma (1/10, 10%). Membrane staining was not observed in any case of malignant lymphoma. These results indicate that aberrant FGFR3 staining may be seen infrequently in many forms of malignant lymphoma, although dysregulation of this pathway does not seem to contribute to lymphomagenesis in the majority of cases. Moreover, these findings suggest at least most patients with malignant lymphomas are unlikely to benefit from novel agents targeting the FGFR3 pathway.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1533-4058
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
322-5
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Fibroblast growth factor receptor 3 (FGFR3) expression in malignant lymphomas.
pubmed:affiliation
Department of Clinical Pathology, Cleveland Clinic, Cleveland, OH 44195, USA.
pubmed:publicationType
Journal Article, Comparative Study