Source:http://linkedlifedata.com/resource/pubmed/id/18525295
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2008-6-5
|
| pubmed:abstractText |
Mutations in 3 genes are known to be deterministic for early-onset familial Alzheimer disease. The genes are presenilin-1, presenilin-2, and amyloid precursor protein. As these genes prove to be negative in patients with a clinical diagnosis of early-onset familial Alzheimer disease, a search for tau gene mutations may be appropriate, as illustrated by the following case.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
1546-4156
|
| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:volume |
22
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
194-5
|
| pubmed:meshHeading |
pubmed-meshheading:18525295-Age of Onset,
pubmed-meshheading:18525295-Alzheimer Disease,
pubmed-meshheading:18525295-Amyloid beta-Protein Precursor,
pubmed-meshheading:18525295-Humans,
pubmed-meshheading:18525295-Introns,
pubmed-meshheading:18525295-Male,
pubmed-meshheading:18525295-Middle Aged,
pubmed-meshheading:18525295-Mutation,
pubmed-meshheading:18525295-Phenotype,
pubmed-meshheading:18525295-Presenilin-1,
pubmed-meshheading:18525295-tau Proteins
|
| pubmed:articleTitle |
Mutation negative "early-onset familial Alzheimer disease": consider screening for tau gene mutations.
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| pubmed:affiliation |
Cognitive Function Clinic, Walton Centre for Neurology and Neurosurgery, Liverpool, UK. a.larner@thewaltoncentre.nhs.uk
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| pubmed:publicationType |
Journal Article,
Case Reports
|