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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2008-6-5
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pubmed:abstractText |
MicroRNAs have essential functional roles in brain development and neuronal specification but their roles in neurodegenerative diseases such as Alzheimer's disease (AD) is unknown. Using a sensitive qRT-PCR platform we identified regional and stage-specific deregulation of miRNA expression in AD patient brains. We used experimental validation in addition to literature to reveal how the deregulated brain microRNAs are biomarkers for known and novel pathways in AD pathogenesis related to amyloid processing, neurogenesis, insulin resistance, and innate immunity. We additionally recovered miRNAs from cerebrospinal fluid and discovered AD-specific miRNA changes consistent with their role as potential biomarkers of disease.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1387-2877
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pubmed:author |
pubmed-author:BrownDavidD,
pubmed-author:CannonBrianB,
pubmed-author:ChenCaifuC,
pubmed-author:CogswellJohn PJP,
pubmed-author:KelnarKevinK,
pubmed-author:KemppainenJonJ,
pubmed-author:PrinjhaRab KRK,
pubmed-author:RichardsCynthia ACA,
pubmed-author:RichardsonJill CJC,
pubmed-author:RosesAllen DAD,
pubmed-author:SaundersAnn MAM,
pubmed-author:ShiYunlingY,
pubmed-author:TaylorIan AIA,
pubmed-author:WardJamesJ,
pubmed-author:WatersMichelleM
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pubmed:issnType |
Print
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
27-41
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:18525125-Aged,
pubmed-meshheading:18525125-Aged, 80 and over,
pubmed-meshheading:18525125-Alzheimer Disease,
pubmed-meshheading:18525125-Amyloid,
pubmed-meshheading:18525125-Biological Markers,
pubmed-meshheading:18525125-Brain,
pubmed-meshheading:18525125-Cell Line, Tumor,
pubmed-meshheading:18525125-Cerebellum,
pubmed-meshheading:18525125-Female,
pubmed-meshheading:18525125-Frontal Lobe,
pubmed-meshheading:18525125-Gene Expression Regulation,
pubmed-meshheading:18525125-Genetic Markers,
pubmed-meshheading:18525125-Hippocampus,
pubmed-meshheading:18525125-Humans,
pubmed-meshheading:18525125-Immunity, Innate,
pubmed-meshheading:18525125-Insulin Resistance,
pubmed-meshheading:18525125-Male,
pubmed-meshheading:18525125-MicroRNAs,
pubmed-meshheading:18525125-Middle Aged,
pubmed-meshheading:18525125-Neurons,
pubmed-meshheading:18525125-RNA, Messenger,
pubmed-meshheading:18525125-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:18525125-Transfection
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pubmed:year |
2008
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pubmed:articleTitle |
Identification of miRNA changes in Alzheimer's disease brain and CSF yields putative biomarkers and insights into disease pathways.
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pubmed:affiliation |
Department of Pharmacogenetics, GlaxoSmithKline Inc., Research Triangle Park, NC 27709, USA. John.P.Cogswell@gsk.com
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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