Source:http://linkedlifedata.com/resource/pubmed/id/18524605
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
12
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pubmed:dateCreated |
2008-6-13
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pubmed:abstractText |
The synthesis and biological evaluation of novel prodrugs based on the cytotoxic antibiotic duocarmycin SA (1) for a selective treatment of cancer using a prodrug monotherapy (PMT) are described. Transformation of the phenol 8 with the glucuronic acid benzyl ester trichloroacetimidate 9b followed by reaction with DMAI x HCl (10) gives the glucuronide 11b, which is deprotected to afford the desired prodrug 4a containing a glucuronic acid moiety. In addition, the prodrug 4b with a glucuronic methyl ester unit is prepared. The cytotoxicity of the glucuronides is determined using a HTCFA-assay with IC(50) values of 610 nM for 4a and 3300 nM for 4b. In the presence of beta-glucuronidase, 4a expresses an IC(50) value of 0.9 nM and 4b of 2.1 nM resulting in QIC(50) values of about 700 for 4a and 1600 for 4b.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Glucuronic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Glucuronic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Indoles,
http://linkedlifedata.com/resource/pubmed/chemical/Prodrugs,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrroles,
http://linkedlifedata.com/resource/pubmed/chemical/duocarmycin SA
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1464-3391
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pubmed:author | |
pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6312-8
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pubmed:meshHeading |
pubmed-meshheading:18524605-Antineoplastic Agents,
pubmed-meshheading:18524605-Cell Line, Tumor,
pubmed-meshheading:18524605-Glucuronic Acid,
pubmed-meshheading:18524605-Glucuronic Acids,
pubmed-meshheading:18524605-Humans,
pubmed-meshheading:18524605-Indoles,
pubmed-meshheading:18524605-Inhibitory Concentration 50,
pubmed-meshheading:18524605-Neoplasms,
pubmed-meshheading:18524605-Prodrugs,
pubmed-meshheading:18524605-Pyrroles
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pubmed:year |
2008
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pubmed:articleTitle |
Duocarmycin-based prodrugs for cancer prodrug monotherapy.
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pubmed:affiliation |
Institute of Organic und Biomolecular Chemistry of the Georg-August-University Göttingen, D-37077 Göttingen, Germany. ltietze@gwdg.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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