|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
9
|
|
pubmed:dateCreated |
2008-8-28
|
|
pubmed:abstractText |
The frequency of LRRK2 Gly2385Arg mutation in Hong Kong Chinese with early-onset (age < or =45 years) Parkinson's disease was identified and compared with late-onset patients (age >50 years) and controls. The mutation prevalence were 8.8, 8.3, and 0% for early-onset, late-onset, and controls, respectively. The mean age of onset among LRRK2 G2385R carriers was 42.7 years old for early-onset compared to 74.3 for late-onset patients. LRRK2 G2385R mutation appears to be as prevalent among early-onset as late-onset patients.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
0300-9564
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
115
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1275-7
|
|
pubmed:dateRevised |
2009-11-19
|
|
pubmed:meshHeading |
pubmed-meshheading:18523722-Adult,
pubmed-meshheading:18523722-Age Factors,
pubmed-meshheading:18523722-Age of Onset,
pubmed-meshheading:18523722-Aged,
pubmed-meshheading:18523722-Aged, 80 and over,
pubmed-meshheading:18523722-Amino Acid Substitution,
pubmed-meshheading:18523722-Asian Continental Ancestry Group,
pubmed-meshheading:18523722-DNA Mutational Analysis,
pubmed-meshheading:18523722-Female,
pubmed-meshheading:18523722-Gene Frequency,
pubmed-meshheading:18523722-Genetic Markers,
pubmed-meshheading:18523722-Genetic Predisposition to Disease,
pubmed-meshheading:18523722-Genetic Testing,
pubmed-meshheading:18523722-Genotype,
pubmed-meshheading:18523722-Hong Kong,
pubmed-meshheading:18523722-Humans,
pubmed-meshheading:18523722-Male,
pubmed-meshheading:18523722-Middle Aged,
pubmed-meshheading:18523722-Mutation,
pubmed-meshheading:18523722-Parkinson Disease,
pubmed-meshheading:18523722-Prevalence,
pubmed-meshheading:18523722-Protein-Serine-Threonine Kinases
|
|
pubmed:year |
2008
|
|
pubmed:articleTitle |
LRRK2 Gly2385Arg mutation and clinical features in a Chinese population with early-onset Parkinson's disease compared to late-onset patients.
|
|
pubmed:affiliation |
Department of Aged Care and Rehabilitation, Bankstown-Lidcombe Hospital, Locked bag 1600, Bankstown, NSW 2200, Australia. daniel.chan@sswahs.nsw.gov.au
|
|
pubmed:publicationType |
Journal Article,
Comparative Study
|
