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rdf:type |
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lifeskim:mentions |
umls-concept:C0009221,
umls-concept:C0013682,
umls-concept:C0019704,
umls-concept:C0035696,
umls-concept:C0039194,
umls-concept:C0040711,
umls-concept:C0205266,
umls-concept:C0328767,
umls-concept:C0392762,
umls-concept:C0457083,
umls-concept:C0679058,
umls-concept:C1280500,
umls-concept:C1547699,
umls-concept:C2700640
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pubmed:issue |
6
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pubmed:dateCreated |
2008-6-4
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pubmed:abstractText |
The sequences of wild-isolate strains of Human Immunodeficiency Virus-1 (HIV-1) are characterized by low GC content and suboptimal codon usage. Codon optimization of DNA vectors can enhance protein expression both by enhancing translational efficiency, and by altering RNA stability and export. Although gag codon optimization is widely used in DNA vectors and experimental vaccines, the actual effect of altered codon usage on gag translational efficiency has not been quantified.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18523584-10690406,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18523584-11035115,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18523584-11602739,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18523584-11680853,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18523584-12388704,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18523584-12639249,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18523584-12683241,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18523584-12683242,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18523584-12808466,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18523584-12970355,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18523584-14557052,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18523584-14585212,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18523584-15015498,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18523584-15233739,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18523584-15650426,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18523584-16249391,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18523584-16263796,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18523584-8548660,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18523584-8805248,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18523584-9188551,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18523584-9891806
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1932-6203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
3
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e2356
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:18523584-Codon,
pubmed-meshheading:18523584-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:18523584-Gene Products, gag,
pubmed-meshheading:18523584-HIV-1,
pubmed-meshheading:18523584-Humans,
pubmed-meshheading:18523584-Jurkat Cells,
pubmed-meshheading:18523584-Protein Biosynthesis,
pubmed-meshheading:18523584-RNA, Messenger,
pubmed-meshheading:18523584-T-Lymphocytes
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pubmed:year |
2008
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pubmed:articleTitle |
Quantitative effect of suboptimal codon usage on translational efficiency of mRNA encoding HIV-1 gag in intact T cells.
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pubmed:affiliation |
HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu Natal, Durban, South Africa.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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