Source:http://linkedlifedata.com/resource/pubmed/id/18523259
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
12
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| pubmed:dateCreated |
2008-6-4
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| pubmed:abstractText |
Recent reports have shown that IL-21, in synergy with IL-15, stimulates proliferation of CD8(+) T lymphocytes in the absence of signaling via the TCR. In this study, we show that IL-6, which induces phosphorylation of STAT3 similarly to IL-21, also can stimulate proliferation of CD8(+) T cells in synergy with IL-7 or IL-15. IL-6 displays a stronger synergy with IL-7 than with IL-15 to stimulate naive CD8(+) T cells. Concomitant stimulation by IL-6 or IL-21 augments phosphorylation and DNA-binding activity of STAT5 induced by IL-7 or IL-15. Like IL-21, IL-6 reduces the TCR signaling threshold required to stimulate CD8(+) T cells. Prior culture of P14 TCR transgenic CD8 T cells with IL-6 or IL-21 in the presence of IL-7 or IL-15 augments their proliferation and cytolytic activity upon subsequent stimulation by Ag. Furthermore, cytokine stimulation induces quantitatively and qualitatively distinct phenotypic changes on CD8(+) T cells compared with those induced by TCR signaling. We propose that the ability of IL-6 to induce TCR-independent activation of CD8(+) T cells in synergy with IL-7 or IL-15 may play an important role in the transition from innate to adaptive immunity.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adjuvants, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-15,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-7,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jun
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| pubmed:issn |
0022-1767
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:day |
15
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| pubmed:volume |
180
|
| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
7958-68
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| pubmed:dateRevised |
2008-11-21
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| pubmed:meshHeading |
pubmed-meshheading:18523259-Adjuvants, Immunologic,
pubmed-meshheading:18523259-Animals,
pubmed-meshheading:18523259-CD8-Positive T-Lymphocytes,
pubmed-meshheading:18523259-Cell Differentiation,
pubmed-meshheading:18523259-Cell Line, Tumor,
pubmed-meshheading:18523259-Cell Proliferation,
pubmed-meshheading:18523259-Cells, Cultured,
pubmed-meshheading:18523259-G0 Phase,
pubmed-meshheading:18523259-Immunity, Innate,
pubmed-meshheading:18523259-Immunologic Memory,
pubmed-meshheading:18523259-Immunophenotyping,
pubmed-meshheading:18523259-Interleukin-15,
pubmed-meshheading:18523259-Interleukin-6,
pubmed-meshheading:18523259-Interleukin-7,
pubmed-meshheading:18523259-Lymphocyte Activation,
pubmed-meshheading:18523259-Male,
pubmed-meshheading:18523259-Mice,
pubmed-meshheading:18523259-Mice, Inbred C57BL,
pubmed-meshheading:18523259-Mice, Knockout,
pubmed-meshheading:18523259-Mice, Transgenic,
pubmed-meshheading:18523259-Receptors, Antigen, T-Cell
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| pubmed:year |
2008
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| pubmed:articleTitle |
IL-6, in synergy with IL-7 or IL-15, stimulates TCR-independent proliferation and functional differentiation of CD8+ T lymphocytes.
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| pubmed:affiliation |
Immunology Division, Department of Pediatrics, University of Sherbrooke, Québec, Canada.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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