Linked Life Data

1852165

Source:http://linkedlifedata.com/resource/pubmed/id/1852165

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1991-8-21
pubmed:databankReference
pubmed:abstractText
The phosphoglycerate kinase (PGK) gene complex of Trypanosoma brucei contains three tandemly linked related genes. One gene encodes a cytoplasmic PGK, while another encodes a PGK isozyme localized to glycosomal microbodies. In this communication, we report that the third gene in this complex encodes a 56-kDa molecule which is also localized to the glycosomal core. DNA sequence analysis indicates that this gene contains multiple substitutions and a large insertion in the amino domain, but that it is very similar to the other PGK isozymes in the carboxy domain. The C-terminal tripeptide is identical to that of the cytoplasmic isozyme, and only one conservative change occurs in the last 25 amino acids. The encoded protein, p56, thus contrasts with the many peroxisomal microbody proteins in which the C-terminal tripeptide contains sufficient information for targeting to peroxisomes. Multiple mechanisms may exist for targeting proteins to the protein cores of microbody organelles. Comparisons of the DNA sequences of several alleles suggest that homologous recombination plays a role in the generation of allelic diversity.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0166-6851
pubmed:author
pubmed:issnType
Print
pubmed:volume
46
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1-10
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
A phosphoglycerate kinase-like molecule localized to glycosomal microbodies: evidence that the topogenic signal is not at the C-terminus.
pubmed:affiliation
Seattle Biomedical Research Institute, University of Washington, Seattle.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't