Source:http://linkedlifedata.com/resource/pubmed/id/18521207
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2008-6-3
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| pubmed:abstractText |
Purpose. This paper describes the clinical history and radiographic appearance of second malignancies in patients with bilateral retinoblastoma.Subjects/methods. The imaging studies and clinical data of 14 patients with a history of bilateral retinoblastoma who were treated for second malignancies were reviewed.Results. A total of 17 tumors were identified in 14 patients during the period 1978-1996. The median age of occurrence of the second malignancy was 17 years (range 10-32 years). Fourteen of the 17 malignancies occurred in the facial structures and three developed in the lower extremities. The histologies included osteosarcoma (n = 5), malignant fibrous histiocytoma (n = 3), high-grade spindle cell sarcoma (n = 3), malignant mesenchymoma (n = 1), leiomyosarcoma (n = 4) and angiosarcoma (n = 1). The tumors were locally aggressive and had a similar appearance to those found in nonretinoblastoma patients. Six of the 14 patients are alive and disease free.Discussion. Most of the adolescent and young adult retinoblastoma survivors developed second malignancies in the irradiated facial structures but some occurred in distal sites. Radiologically, these tumors do not differ in appearance from those seen in non-retinoblastoma patients with the exception of their location.
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| pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18521207-14081487,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18521207-2822073,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18521207-2994066,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18521207-3478072,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18521207-5775011,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18521207-626181,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18521207-6595610,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18521207-6841169,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18521207-7422244,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18521207-8320741,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18521207-980006
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:status |
PubMed-not-MEDLINE
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| pubmed:issn |
1357-714X
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
1
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
89-93
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| pubmed:year |
1997
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| pubmed:articleTitle |
The location and appearance of second malignancies in patients with bilateral retinoblastoma.
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| pubmed:affiliation |
Department of Radiology Memorial Sloan Kettering Cancer Center 1275 York Avenue New York NY 10021 USA.
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| pubmed:publicationType |
Journal Article
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