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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5 Pt 1
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pubmed:dateCreated |
1991-6-21
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pubmed:abstractText |
Protein C is a vitamin K-dependent regulator of blood coagulation. Activated protein C is regulated in plasma in large part by two inhibitors, protein C inhibitor and alpha 1-antitrypsin. Complexes of activated protein C with both inhibitors in plasma samples from subjects with normal or pathologic pregnancy were measured. In normal pregnancy we observed a progressive and significant increase in activated protein C/alpha 1-antitrypsin complex levels, from 9 +/- 3 ng/ml in the first trimester to 16 +/- 3 ng/ml in the third trimester, as well as an increase in alpha 1-antitrypsin plasma levels. In severe preeclampsia, but not in chronic hypertension with superimposed severe preeclampsia, there was a greater increase in activated protein C/alpha 1-antitrypsin levels (25 +/- 10 ng/ml) (p less than 0.001) and a decrease in protein C and protein C inhibitor levels as compared with normal pregnant women at similar gestational ages. These data show an increase in the activation of the protein C pathway in both normal and pathologic pregnancy and provide evidence for an enhancement of thrombin generation in severe preeclampsia compared with chronic hypertension with superimposed severe preeclampsia.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0002-9378
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
164
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1310-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1852102-Adolescent,
pubmed-meshheading:1852102-Adult,
pubmed-meshheading:1852102-Alanine Transaminase,
pubmed-meshheading:1852102-Analysis of Variance,
pubmed-meshheading:1852102-Aspartate Aminotransferases,
pubmed-meshheading:1852102-Blood Proteins,
pubmed-meshheading:1852102-Creatinine,
pubmed-meshheading:1852102-Diagnosis, Differential,
pubmed-meshheading:1852102-Female,
pubmed-meshheading:1852102-Gestational Age,
pubmed-meshheading:1852102-Humans,
pubmed-meshheading:1852102-Hypertension,
pubmed-meshheading:1852102-L-Lactate Dehydrogenase,
pubmed-meshheading:1852102-Pre-Eclampsia,
pubmed-meshheading:1852102-Pregnancy,
pubmed-meshheading:1852102-Pregnancy Complications, Cardiovascular,
pubmed-meshheading:1852102-Protein C,
pubmed-meshheading:1852102-Protein C Inhibitor,
pubmed-meshheading:1852102-Serine Proteinase Inhibitors,
pubmed-meshheading:1852102-alpha 1-Antitrypsin
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pubmed:year |
1991
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pubmed:articleTitle |
Complexes of activated protein C with alpha 1-antitrypsin in normal pregnancy and in severe preeclampsia.
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pubmed:affiliation |
Research Center Hospital La Fe, Valencia, Spain.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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