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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2008-6-3
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pubmed:abstractText |
MDM2 is a key negative regulator of p53 activity, and a single nucleotide polymorphism (SNP309, T>G change; rs 2279744) in its promoter increases the affinity for the transcription factor SP1, enhancing MDM2 expression. We carried out a pilot study to investigate the effect of this polymorphism on development and behavior of neuroblastoma, an extracranial pediatric tumor with unfrequent genetic inactivation of p53.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1078-0432
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pubmed:author |
pubmed-author:AltavistaPierluigiP,
pubmed-author:BertorelleRobertaR,
pubmed-author:BoldriniRenataR,
pubmed-author:BussolariRitaR,
pubmed-author:CalabrettaBrunoB,
pubmed-author:CandiniOliviaO,
pubmed-author:CattelaniSaraS,
pubmed-author:CorradiniFrancescaF,
pubmed-author:DefferrariRaffaellaR,
pubmed-author:DominiciCarloC,
pubmed-author:Ferrari-AmorottiGiovannaG,
pubmed-author:GuerzoniClaraC,
pubmed-author:MarsilioSoniaS,
pubmed-author:McDowellHeather PHP,
pubmed-author:MeninChiaraC,
pubmed-author:PecorariLuisaL,
pubmed-author:RaschellàGiuseppeG,
pubmed-author:ToniniGian PaoloGP
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3248-53
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:18519749-Child,
pubmed-meshheading:18519749-Child, Preschool,
pubmed-meshheading:18519749-Genetic Predisposition to Disease,
pubmed-meshheading:18519749-Humans,
pubmed-meshheading:18519749-Infant,
pubmed-meshheading:18519749-Kaplan-Meier Estimate,
pubmed-meshheading:18519749-Neuroblastoma,
pubmed-meshheading:18519749-Pilot Projects,
pubmed-meshheading:18519749-Polymerase Chain Reaction,
pubmed-meshheading:18519749-Polymorphism, Single Nucleotide,
pubmed-meshheading:18519749-Proto-Oncogene Proteins c-mdm2
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pubmed:year |
2008
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pubmed:articleTitle |
Impact of a single nucleotide polymorphism in the MDM2 gene on neuroblastoma development and aggressiveness: results of a pilot study on 239 patients.
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pubmed:affiliation |
Department of Biomedical Sciences and Oncology, Modena and Reggio Emilia University, Modena, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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