Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1991-6-26
pubmed:databankReference
pubmed:abstractText
The genome and transcriptional pattern of a newly identified respiratory variant of transmissible gastroenteritis virus were analyzed and compared with those of classical enterotropic transmissible gastroenteritis virus. The transcriptional patterns of the two viruses indicated that differences occurred in RNAs 1 and 2(S) and that RNA 3 was absent in the porcine respiratory coronavirus (PRCV) variant. The smaller RNA 2(S) of PRCV was due to a 681-nucleotide (nt) deletion after base 62 of the PRCV peplomer or spike (S) gene. The PRCV S gene still retained information for the 16-amino-acid signal peptide and the first 6 amino acid residues at the N terminus of the mature S protein, but the adjacent 227 residues were deleted. Two additional deletions (3 and 5 nt) were detected in the PRCV genome downstream of the S gene. The 3-nt deletion occurred in a noncoding region; however, the 5-nt deletion shortened the potential open reading frame A polypeptide from 72 to 53 amino acid residues. Significantly, a C-to-T substitution was detected in the last base position of the transcription recognition sequence upstream of open reading frame A, which rendered RNA 3 nondetectable in PRCV-infected cell cultures.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/1851885-166796, http://linkedlifedata.com/resource/pubmed/commentcorrection/1851885-1688627, http://linkedlifedata.com/resource/pubmed/commentcorrection/1851885-1962975, http://linkedlifedata.com/resource/pubmed/commentcorrection/1851885-1965638, http://linkedlifedata.com/resource/pubmed/commentcorrection/1851885-1966416, http://linkedlifedata.com/resource/pubmed/commentcorrection/1851885-1985203, http://linkedlifedata.com/resource/pubmed/commentcorrection/1851885-203563, http://linkedlifedata.com/resource/pubmed/commentcorrection/1851885-2168963, http://linkedlifedata.com/resource/pubmed/commentcorrection/1851885-2169676, http://linkedlifedata.com/resource/pubmed/commentcorrection/1851885-2174956, http://linkedlifedata.com/resource/pubmed/commentcorrection/1851885-2252386, http://linkedlifedata.com/resource/pubmed/commentcorrection/1851885-2384915, http://linkedlifedata.com/resource/pubmed/commentcorrection/1851885-2546161, http://linkedlifedata.com/resource/pubmed/commentcorrection/1851885-2546515, http://linkedlifedata.com/resource/pubmed/commentcorrection/1851885-2549745, http://linkedlifedata.com/resource/pubmed/commentcorrection/1851885-2550577, http://linkedlifedata.com/resource/pubmed/commentcorrection/1851885-2556846, http://linkedlifedata.com/resource/pubmed/commentcorrection/1851885-271968, http://linkedlifedata.com/resource/pubmed/commentcorrection/1851885-2825819, http://linkedlifedata.com/resource/pubmed/commentcorrection/1851885-3014051, http://linkedlifedata.com/resource/pubmed/commentcorrection/1851885-3018993, http://linkedlifedata.com/resource/pubmed/commentcorrection/1851885-3037011, http://linkedlifedata.com/resource/pubmed/commentcorrection/1851885-3516005, http://linkedlifedata.com/resource/pubmed/commentcorrection/1851885-4224292, http://linkedlifedata.com/resource/pubmed/commentcorrection/1851885-6654644
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0022-538X
pubmed:author
pubmed:issnType
Print
pubmed:volume
65
pubmed:geneSymbol
PRCV, S
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3369-73
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Genetic analysis of porcine respiratory coronavirus, an attenuated variant of transmissible gastroenteritis virus.
pubmed:affiliation
National Animal Disease Center, U.S. Department of Agriculture, Ames, Iowa 50010.
pubmed:publicationType
Journal Article, Comparative Study