Linked Life Data

18516987

Source:http://linkedlifedata.com/resource/pubmed/id/18516987

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2008-6-3
pubmed:abstractText
Repeated administration of psychostimulants in rodents can enhance the stimulating effect on locomotor activity, a phenomenon called behavioral sensitization. This has been widely used as animal models for schizophrenia as well as addiction and psychosis, because of the similarity to its process in acquisition and progression. However, there are no studies demonstrating whether the drugs improve the psychostimulant-induced behavioral sensitization when administered after establishment of the sensitization, while previous studies have mainly focused on the analyses of the development (induction) phase of the sensitization. We demonstrated that the activation of serotonin (5-HT) receptors or blockade of 5-HT2 receptors, given after establishment of the sensitization, attenuates the expression of methamphetamine-induced behavioral sensitization in mice. In addition, we also showed that repeated administration of methamphetamine induces the increased reactivity of prefrontal serotonergic neurons specifically. These observations suggest that the 5-HT system is a neurochemical basis for the behavioral sensitization, and imply that 5-HT1A and 5-HT2 receptors may have potential therapeutic values in the remission of methamphetamine abuse or psychosis. Here, we provide an overview of the roles of serotonergic neurons in the psychostimulant-induced behavioral sensitization.
pubmed:language
jpn
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1340-2544
pubmed:author
pubmed:issnType
Print
pubmed:volume
28
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
85-91
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:18516987-Animals, pubmed-meshheading:18516987-Central Nervous System Stimulants, pubmed-meshheading:18516987-Disease Models, Animal, pubmed-meshheading:18516987-Humans, pubmed-meshheading:18516987-Methamphetamine, pubmed-meshheading:18516987-Mice, pubmed-meshheading:18516987-Motor Activity, pubmed-meshheading:18516987-Neurons, pubmed-meshheading:18516987-Prefrontal Cortex, pubmed-meshheading:18516987-Psychoses, Substance-Induced, pubmed-meshheading:18516987-Receptor, Serotonin, 5-HT1A, pubmed-meshheading:18516987-Receptors, Serotonin, 5-HT2, pubmed-meshheading:18516987-Serotonin, pubmed-meshheading:18516987-Serotonin 5-HT1 Receptor Antagonists, pubmed-meshheading:18516987-Serotonin 5-HT2 Receptor Antagonists, pubmed-meshheading:18516987-Stimulation, Chemical, pubmed-meshheading:18516987-Substance-Related Disorders
pubmed:year
2008
pubmed:articleTitle
[Involvement of prefrontal serotonergic neurons in methamphetamine-induced behavioral sensitization].
pubmed:affiliation
Laboratory of Medicinal Pharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, 565-0871, Japan.
pubmed:publicationType
Journal Article, English Abstract, Review