Source:http://linkedlifedata.com/resource/pubmed/id/18516037
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
|
| pubmed:dateCreated |
2008-6-19
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| pubmed:abstractText |
The intestinal cell types responsible for defense against pathogenic organisms remain incompletely characterized. Here we identify a subset of CD11c(hi)CD11b(hi) lamina propria dendritic cells (LPDCs) that expressed Toll-like receptor 5 (TLR5) in the small intestine. When stimulated by the TLR5 ligand flagellin, TLR5(+) LPDCs induced the differentiation of naive B cells into immunoglobulin A-producing plasma cells by a mechanism independent of gut-associated lymphoid tissue. In addition, by a mechanism dependent on TLR5 stimulation, these LPDCs promoted the differentiation of antigen-specific interleukin 17-producing T helper cells and type 1 T helper cells. Unlike spleen DCs, the LPDCs specifically produced retinoic acid, which, in a dose-dependent way, supported the generation and retention of immunoglobulin A-producing cells in the lamina propria and positively regulated the differentiation interleukin 17-producing T helper cells. Our findings demonstrate unique properties of LPDCs and the importance of TLR5 for adaptive immunity in the intestine.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
1529-2916
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| pubmed:author |
pubmed-author:AkiraShizuoS,
pubmed-author:FujimotoKosukeK,
pubmed-author:IshiiKen JKJ,
pubmed-author:JangMyoung HoMH,
pubmed-author:JungYun-JaeYJ,
pubmed-author:KiyonoHiroshiH,
pubmed-author:MiyasakaMasayukiM,
pubmed-author:NishiyamaMikaM,
pubmed-author:SatoShintaroS,
pubmed-author:TsujimuraTohruT,
pubmed-author:UematsuSatoshiS,
pubmed-author:YamamotoMasafumiM,
pubmed-author:YangBo-GieBG,
pubmed-author:YokotaYoshifumiY
|
| pubmed:issnType |
Electronic
|
| pubmed:volume |
9
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
769-76
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| pubmed:meshHeading |
pubmed-meshheading:18516037-Animals,
pubmed-meshheading:18516037-Antibody Formation,
pubmed-meshheading:18516037-B-Lymphocytes,
pubmed-meshheading:18516037-Cells, Cultured,
pubmed-meshheading:18516037-Dendritic Cells,
pubmed-meshheading:18516037-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:18516037-Flagellin,
pubmed-meshheading:18516037-Flow Cytometry,
pubmed-meshheading:18516037-Immunity, Cellular,
pubmed-meshheading:18516037-Immunity, Mucosal,
pubmed-meshheading:18516037-Immunoglobulin A,
pubmed-meshheading:18516037-Immunohistochemistry,
pubmed-meshheading:18516037-Lymphocyte Activation,
pubmed-meshheading:18516037-Mice,
pubmed-meshheading:18516037-Mucous Membrane,
pubmed-meshheading:18516037-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:18516037-T-Lymphocytes,
pubmed-meshheading:18516037-Toll-Like Receptor 5,
pubmed-meshheading:18516037-Tretinoin
|
| pubmed:year |
2008
|
| pubmed:articleTitle |
Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5.
|
| pubmed:affiliation |
Laboratory of Host Defense, Immunology Frontier Research Center, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|