Source:http://linkedlifedata.com/resource/pubmed/id/18515161
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions |
umls-concept:C0001811,
umls-concept:C0002395,
umls-concept:C0019638,
umls-concept:C0025260,
umls-concept:C0026336,
umls-concept:C0026809,
umls-concept:C0040223,
umls-concept:C0205171,
umls-concept:C0392747,
umls-concept:C0443172,
umls-concept:C0872341,
umls-concept:C1513264,
umls-concept:C1515926,
umls-concept:C1522424,
umls-concept:C1551359
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| pubmed:issue |
2
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| pubmed:dateCreated |
2008-8-11
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| pubmed:abstractText |
Tg2576 mice over-expressing human mutant APP (hAPPswe) show progressive impairments in hippocampal plasticity and episodic memory while fronto-striatal plasticity and procedural memory remain intact. Here we examine the status of synaptic connectivity in the hippocampus and the dorsolateral striatum (DLS) of 3- and 15-month-old Tg2576 and wild-type mice through the analysis of single dendritic spines microanatomy. We found that, in each region, all mice showed a global reduction in the size of spines as a function of age. Ageing mutants, however, exhibited smaller spines with shorter necks on CA1 pyramidal neurons but larger spines with longer necks on DLS spiny neurons compared to their age-matched wild-type controls. Our findings indicate that hippocampal and DLS dendritic spines in hAPPswe mutants undergo a different pattern of morphological changes over time and point to minor alterations in the microanatomy of DLS spines as a compensatory mechanism maintaining procedural abilities in the ageing mutants.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Sep
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| pubmed:issn |
1095-9564
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
90
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
467-71
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| pubmed:meshHeading |
pubmed-meshheading:18515161-Aging,
pubmed-meshheading:18515161-Alzheimer Disease,
pubmed-meshheading:18515161-Amyloid beta-Protein Precursor,
pubmed-meshheading:18515161-Animals,
pubmed-meshheading:18515161-Brain,
pubmed-meshheading:18515161-Corpus Striatum,
pubmed-meshheading:18515161-DNA Mutational Analysis,
pubmed-meshheading:18515161-Dendritic Spines,
pubmed-meshheading:18515161-Disease Models, Animal,
pubmed-meshheading:18515161-Frontal Lobe,
pubmed-meshheading:18515161-Hippocampus,
pubmed-meshheading:18515161-Male,
pubmed-meshheading:18515161-Mental Recall,
pubmed-meshheading:18515161-Mice,
pubmed-meshheading:18515161-Mice, Neurologic Mutants,
pubmed-meshheading:18515161-Mice, Transgenic,
pubmed-meshheading:18515161-Nerve Net,
pubmed-meshheading:18515161-Neuronal Plasticity,
pubmed-meshheading:18515161-Neurons
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| pubmed:year |
2008
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| pubmed:articleTitle |
Region-specific changes in the microanatomy of single dendritic spines over time might account for selective memory alterations in ageing hAPPsweTg2576 mice, a mouse model for Alzheimer disease.
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| pubmed:affiliation |
CNR Institute for Neuroscience, S. Lucia Foundation, Via del Fosso di Fiorano 64/65, 00143 Rome, Italy. s.middei@hsantalucia.it
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| pubmed:publicationType |
Journal Article
|