Source:http://linkedlifedata.com/resource/pubmed/id/18514708
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2008-6-27
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| pubmed:abstractText |
We hypothesize that combining angiopoietin-1 (ANG-1) or ANG-2 with vascular endothelial growth factor (VEGF) improves myocardial perfusion and contractile function by modulating vascular adaptation of neoangiogenic microvessels in a chronic ischemic swine model. Four weeks after occlusion of the left circumflex coronary artery (LCx), animals were injected with AdVEGF(165) (n=6), AdVEGF(165)+AdANG-1 (n=6), AdVEGF(165)+AdANG-2 (n=6) or control vector (n=5) into the left ventricular posterolateral wall. Regional perfusion by fluorescent microspheres and segmental myocardial tissue velocity by tissue Doppler imaging (TDI) were assessed at baseline, 4 weeks post occlusion and 4 weeks post therapy. Despite similar vascular growth following VEGF+ANG-1 and VEGF+ANG-2 treatments, transmural myocardial contractility improved only when VEGF was paired with ANG-1. In contrast, regional systolic function deteriorated uniformly across subepicardial, mid-myocardial and subendocardial segments in VEGF and VEGF+ANG-2 treated groups. Contractile improvement was associated with enhanced vascular stability through augmented arteriole formation, tight structural integration between VE-cadherin and beta-catenin at endothelial junctions and improved cross-talk between endothelium and myocardium. Structural stability of developing intramyocardial microvessels contributes to systolic function during ischemic neovascularization. Coordinated regulation of angiogenic revascularization that supports vascular stability is a key aspect in improving therapeutic outcomes in ischemic myocardium.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Angiopoietin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Angiopoietin-2,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Cadherins,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factor A,
http://linkedlifedata.com/resource/pubmed/chemical/beta Catenin,
http://linkedlifedata.com/resource/pubmed/chemical/cadherin 5
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jul
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| pubmed:issn |
1095-8584
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
45
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
70-80
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| pubmed:meshHeading |
pubmed-meshheading:18514708-Adenoviridae,
pubmed-meshheading:18514708-Angiopoietin-1,
pubmed-meshheading:18514708-Angiopoietin-2,
pubmed-meshheading:18514708-Animals,
pubmed-meshheading:18514708-Antigens, CD,
pubmed-meshheading:18514708-Arterioles,
pubmed-meshheading:18514708-Cadherins,
pubmed-meshheading:18514708-Chronic Disease,
pubmed-meshheading:18514708-Coronary Circulation,
pubmed-meshheading:18514708-Coronary Vessels,
pubmed-meshheading:18514708-Disease Models, Animal,
pubmed-meshheading:18514708-Echocardiography, Doppler,
pubmed-meshheading:18514708-Endothelium,
pubmed-meshheading:18514708-Female,
pubmed-meshheading:18514708-Gene Therapy,
pubmed-meshheading:18514708-Male,
pubmed-meshheading:18514708-Myocardial Contraction,
pubmed-meshheading:18514708-Myocardial Ischemia,
pubmed-meshheading:18514708-Myocardium,
pubmed-meshheading:18514708-Neovascularization, Physiologic,
pubmed-meshheading:18514708-Recovery of Function,
pubmed-meshheading:18514708-Swine,
pubmed-meshheading:18514708-Time Factors,
pubmed-meshheading:18514708-Vascular Endothelial Growth Factor A,
pubmed-meshheading:18514708-beta Catenin
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| pubmed:year |
2008
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| pubmed:articleTitle |
Structural stability of neoangiogenic intramyocardial microvessels supports functional recovery in chronic ischemic myocardium.
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| pubmed:affiliation |
Research and Development Unit, National Heart Center, Singapore. Winston_SHIM_SN@nhc.com.sg
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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