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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2008-10-30
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pubmed:abstractText |
Peripheral benzodiazepine receptor (PBR) in the brain of Alzheimer's disease (AD) patients has been discussed in relation to the role of gliosis in AD. The PBR was shown to have the ability to reflect activated glial cells, including microglia. The role of activated microglia in AD is an important topic in the pathophysiology of AD. The aim of this study was to quantify PBR in AD brain with a new high-sensitive PBR ligand, [(11)C]DAA1106.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1873-2402
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pubmed:author |
pubmed-author:AsadaTakashiT,
pubmed-author:DoronbekovTalant KTK,
pubmed-author:FujimuraYotaY,
pubmed-author:HiguchiMakotoM,
pubmed-author:ItoHiroshiH,
pubmed-author:KoedaMichihikoM,
pubmed-author:KosakaJunJ,
pubmed-author:NozakiShokoS,
pubmed-author:OranOO,
pubmed-author:SuharaTetsuyaT,
pubmed-author:YasunoFumihikoF
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
64
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
835-41
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pubmed:meshHeading |
pubmed-meshheading:18514164-Acetamides,
pubmed-meshheading:18514164-Alzheimer Disease,
pubmed-meshheading:18514164-Brain,
pubmed-meshheading:18514164-Humans,
pubmed-meshheading:18514164-Ligands,
pubmed-meshheading:18514164-Neuroglia,
pubmed-meshheading:18514164-Phenyl Ethers,
pubmed-meshheading:18514164-Positron-Emission Tomography,
pubmed-meshheading:18514164-Protein Binding,
pubmed-meshheading:18514164-Receptors, GABA-A
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pubmed:year |
2008
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pubmed:articleTitle |
Increased binding of peripheral benzodiazepine receptor in Alzheimer's disease measured by positron emission tomography with [11C]DAA1106.
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pubmed:affiliation |
Clinical Neuroimaging Section, Department of Molecular Neuroimaging, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan. yasunof@md.tsukuba.ac.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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