pubmed-article:18513923 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:18513923 | lifeskim:mentions | umls-concept:C0019158 | lld:lifeskim |
pubmed-article:18513923 | lifeskim:mentions | umls-concept:C0524637 | lld:lifeskim |
pubmed-article:18513923 | lifeskim:mentions | umls-concept:C0678226 | lld:lifeskim |
pubmed-article:18513923 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
pubmed-article:18513923 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
pubmed-article:18513923 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
pubmed-article:18513923 | pubmed:issue | 3 | lld:pubmed |
pubmed-article:18513923 | pubmed:dateCreated | 2008-11-25 | lld:pubmed |
pubmed-article:18513923 | pubmed:abstractText | Liver-specific immune reactivity in response to aberrant expression of antigen on the surface of hepatocytes is thought to be a major factor in development of autoimmune hepatitis (AIH). Persistent inflammation develops when these antigens are not eliminated and/or responses are not appropriately regulated. We have developed transgenic mice (OVA-HEP), which express chicken ovalbumin on the surface of hepatocytes. These mice are tolerant to ovalbumin, develop normally and have shown no evidence of liver or other disease up to 2 years of age. Adoptive transfer of naïve ovalbumin-specific T cells into OVA-HEP transgenic mice led to liver-specific inflammation in a dose dependent manner. This hepatic necroinflammation was dependent upon CD8(+) Valpha2 OVA-specific T cells, was limited to the liver, and was augmented by OVA-specific CD4(+) T cell help; but did not result from adoptive transfer of ovalbumin-specific CD4 T cells alone. The response was self-limited but persistent inflammation developed after repeated transfer of antigen-specific T cells. This model of T cell recognition of antigen on hepatocytes may be used to understand many liver-specific aspects of the immune response in autoimmune hepatitis. | lld:pubmed |
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pubmed-article:18513923 | pubmed:language | eng | lld:pubmed |
pubmed-article:18513923 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18513923 | pubmed:citationSubset | IM | lld:pubmed |
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pubmed-article:18513923 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:18513923 | pubmed:month | Nov | lld:pubmed |
pubmed-article:18513923 | pubmed:issn | 0896-8411 | lld:pubmed |
pubmed-article:18513923 | pubmed:author | pubmed-author:AllenPaul MPM | lld:pubmed |
pubmed-article:18513923 | pubmed:author | pubmed-author:PetersMarion... | lld:pubmed |
pubmed-article:18513923 | pubmed:author | pubmed-author:QianPeiqingP | lld:pubmed |
pubmed-article:18513923 | pubmed:author | pubmed-author:BuxbaumJamesJ | lld:pubmed |
pubmed-article:18513923 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:18513923 | pubmed:volume | 31 | lld:pubmed |
pubmed-article:18513923 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:18513923 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:18513923 | pubmed:pagination | 208-15 | lld:pubmed |
pubmed-article:18513923 | pubmed:dateRevised | 2010-9-21 | lld:pubmed |
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pubmed-article:18513923 | pubmed:year | 2008 | lld:pubmed |
pubmed-article:18513923 | pubmed:articleTitle | Hepatitis resulting from liver-specific expression and recognition of self-antigen. | lld:pubmed |
pubmed-article:18513923 | pubmed:affiliation | Division of Gastroenterology, University of California, San Francisco, CA 94143, USA. | lld:pubmed |
pubmed-article:18513923 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:18513923 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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