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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2008-11-25
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pubmed:abstractText |
Liver-specific immune reactivity in response to aberrant expression of antigen on the surface of hepatocytes is thought to be a major factor in development of autoimmune hepatitis (AIH). Persistent inflammation develops when these antigens are not eliminated and/or responses are not appropriately regulated. We have developed transgenic mice (OVA-HEP), which express chicken ovalbumin on the surface of hepatocytes. These mice are tolerant to ovalbumin, develop normally and have shown no evidence of liver or other disease up to 2 years of age. Adoptive transfer of naïve ovalbumin-specific T cells into OVA-HEP transgenic mice led to liver-specific inflammation in a dose dependent manner. This hepatic necroinflammation was dependent upon CD8(+) Valpha2 OVA-specific T cells, was limited to the liver, and was augmented by OVA-specific CD4(+) T cell help; but did not result from adoptive transfer of ovalbumin-specific CD4 T cells alone. The response was self-limited but persistent inflammation developed after repeated transfer of antigen-specific T cells. This model of T cell recognition of antigen on hepatocytes may be used to understand many liver-specific aspects of the immune response in autoimmune hepatitis.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18513923-10477588,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18513923-10807506,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18513923-10946266,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18513923-11313320,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18513923-11313380,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18513923-11343230,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18513923-11869369,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18513923-16172259,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18513923-1691527,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18513923-17087941,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18513923-17116738,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18513923-3052945,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18513923-3496995,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18513923-3678824,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18513923-7503362,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18513923-7666518,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18513923-8078396,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18513923-8228807,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18513923-8403500,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18513923-9064352,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18513923-9089906,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18513923-9141419,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18513923-9396776,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18513923-9485202
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0896-8411
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
31
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
208-15
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pubmed:dateRevised |
2010-9-21
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pubmed:meshHeading |
pubmed-meshheading:18513923-Adoptive Transfer,
pubmed-meshheading:18513923-Animals,
pubmed-meshheading:18513923-Autoantigens,
pubmed-meshheading:18513923-Autoimmunity,
pubmed-meshheading:18513923-CD4-Positive T-Lymphocytes,
pubmed-meshheading:18513923-CD8-Positive T-Lymphocytes,
pubmed-meshheading:18513923-Disease Models, Animal,
pubmed-meshheading:18513923-Gene Expression,
pubmed-meshheading:18513923-Hepatitis, Autoimmune,
pubmed-meshheading:18513923-Hepatocytes,
pubmed-meshheading:18513923-Liver,
pubmed-meshheading:18513923-Mice,
pubmed-meshheading:18513923-Mice, Inbred C57BL,
pubmed-meshheading:18513923-Mice, Transgenic,
pubmed-meshheading:18513923-Ovalbumin
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pubmed:year |
2008
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pubmed:articleTitle |
Hepatitis resulting from liver-specific expression and recognition of self-antigen.
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pubmed:affiliation |
Division of Gastroenterology, University of California, San Francisco, CA 94143, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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