Linked Life Data

1851362

Source:http://linkedlifedata.com/resource/pubmed/id/1851362

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1991-6-7
pubmed:abstractText
We describe three patients with chronic progressive polyneuropathy associated with IgA monoclonal gammopathy. Two patients had a prominent sensory neuropathy and one had a prominent motor neuropathy. Sural nerve biopsies showed axonal degeneration in all cases. In immunocytochemical studies patients' IgG immunostained axons. By Western immunoblot a band of IgG reactivity with an axonal protein of 66 kDa was found. No band of IgA and IgM were found. We suggest the possibility that the IgA monoclonal protein may act as a stimulating factor of preexisting B cell clones eliciting an immune reaction against nerve antigens.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0001-6322
pubmed:author
pubmed:issnType
Print
pubmed:volume
81
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
371-6
pubmed:dateRevised
2007-11-9
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Polyneuropathy associated with IgA monoclonal gammopathy: a hypothesis of its pathogenesis.
pubmed:affiliation
Department of Neurology, University of Milan, S. Raffaele Hospital, Italy.
pubmed:publicationType
Journal Article, Case Reports, Research Support, Non-U.S. Gov't