Linked Life Data

18513138

Source:http://linkedlifedata.com/resource/pubmed/id/18513138

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2008-6-2
pubmed:abstractText
This study explored the time course of conditioned fear response expression. Two neutral male facial expressions served as conditioned stimuli (CS) in a differential trace conditioning that involved either an aversive (n=14) or a nonaversive (n=12) unconditioned stimulus (UCS) in a between-subjects design. Skin conductance response (SCR) to the CSs and startle response magnitudes to acoustic probes presented at early (250 ms) or late (1,750 ms) probe times after CS onset were measured. As expected, conditioned SCR discrimination was observed in both aversive and nonaversive learning, whereas the conditioned potentiation of the startle response was only observed for the aversive UCS condition. Interestingly, conditioned startle discrimination was specific for the later probe time. In contrast, conditioned fear potentiation of the startle response at the early probe time was equally pronounced for CS+ and CS-. These findings suggest that fear-eliciting neural structures are rapidly activated in fear learning, whereas the expression of inhibitory conditioning requires more time, presumably reflecting the involvement of cortical top-down control processes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0735-7044
pubmed:author
pubmed:copyrightInfo
(Copyright) 2008 APA, all rights reserved.
pubmed:issnType
Print
pubmed:volume
122
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
685-96
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
In dubio pro defensio: initial activation of conditioned fear is not cue specific.
pubmed:affiliation
Department of Psychology, University of Greifswald, Franz-Mehring-Strasse 47, 17487, Greifswald, Germany. weike@uni-greifswald.de
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't