Source:http://linkedlifedata.com/resource/pubmed/id/18513120
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
2008-6-2
|
| pubmed:abstractText |
Neuropsin (kallikrein-related peptidase 8) is concentrated in the hippocampus, amygdala, olfactory bulb, and prefrontal cortex. Earlier studies showed that protease deficiency causes a significant impairment of early-phase long-term potentiation in the Schaffer collateral pathway and hippocampus-dependent memory in the Y maze and Morris water maze (Z. Chen et al., 1995; A. Hirata et al., 2001; H. Tamura et al., 2006). In addition to neuropsin's participation in the hippocampal memory, amygdalar and cortical localization of the gene suggests extrahippocampal behavioral function, and the authors therefore examined neuropsin-deficient mice, including tests of sensory motor reflex, open field, light-dark transition, Rota-Rod, elevated plus-maze, hot plate, startle response-prepulse inhibition, Porsolt forced swim, Barnes maze, eight-arm radial maze, and contextual and cued fear conditioning tests. Here, the authors found increased anxiety in neuropsin-deficient mice, suggesting the involvement of this protease in emotional responses.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0735-7044
|
| pubmed:author | |
| pubmed:copyrightInfo |
(Copyright) 2008 APA, all rights reserved.
|
| pubmed:issnType |
Print
|
| pubmed:volume |
122
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
498-504
|
| pubmed:meshHeading |
pubmed-meshheading:18513120-Acoustic Stimulation,
pubmed-meshheading:18513120-Analysis of Variance,
pubmed-meshheading:18513120-Animals,
pubmed-meshheading:18513120-Anxiety,
pubmed-meshheading:18513120-Avoidance Learning,
pubmed-meshheading:18513120-Behavior, Animal,
pubmed-meshheading:18513120-Conditioning (Psychology),
pubmed-meshheading:18513120-Cues,
pubmed-meshheading:18513120-Exploratory Behavior,
pubmed-meshheading:18513120-Fear,
pubmed-meshheading:18513120-Kallikreins,
pubmed-meshheading:18513120-Male,
pubmed-meshheading:18513120-Maze Learning,
pubmed-meshheading:18513120-Mice,
pubmed-meshheading:18513120-Mice, Inbred C57BL,
pubmed-meshheading:18513120-Mice, Knockout,
pubmed-meshheading:18513120-Motor Activity,
pubmed-meshheading:18513120-Neural Inhibition,
pubmed-meshheading:18513120-Pain Measurement,
pubmed-meshheading:18513120-Psychomotor Performance,
pubmed-meshheading:18513120-Startle Reaction
|
| pubmed:year |
2008
|
| pubmed:articleTitle |
Increased anxiety-like behavior in neuropsin (kallikrein-related peptidase 8) gene-deficient mice.
|
| pubmed:affiliation |
Division of Structural Cell Biology, Nara Institute of Science and Technology, Nara, Japan.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|