Source:http://linkedlifedata.com/resource/pubmed/id/18512796
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
2008-6-19
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pubmed:abstractText |
Monosodium urate monohydrate (MSU) crystals are among the most potent proinflammatory stimuli, and an innate immune inflammatory response to the crystal surface is involved in the pathogenesis of gouty arthritis. Release of the crystals into the joint cavity promotes an acute inflammation characterized by massive infiltration of neutrophils, which leads to tissue damage. The aim of the present study was to assess the involvement of the tyrosine kinase Tec in MSU crystal-initiated transduction events in human neutrophils.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0004-3591
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
58
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1866-76
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:18512796-Cells, Cultured,
pubmed-meshheading:18512796-Gout,
pubmed-meshheading:18512796-Gout Suppressants,
pubmed-meshheading:18512796-Humans,
pubmed-meshheading:18512796-Neutrophils,
pubmed-meshheading:18512796-Protein-Tyrosine Kinases,
pubmed-meshheading:18512796-Signal Transduction,
pubmed-meshheading:18512796-Uric Acid
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pubmed:year |
2008
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pubmed:articleTitle |
Crystal-induced neutrophil activation: X. Proinflammatory role of the tyrosine kinase Tec.
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pubmed:affiliation |
Laval University, Quebec, Quebec, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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