| pubmed-article:1851113 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1851113 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:1851113 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:1851113 | lifeskim:mentions | umls-concept:C0226890 | lld:lifeskim |
| pubmed-article:1851113 | lifeskim:mentions | umls-concept:C0205108 | lld:lifeskim |
| pubmed-article:1851113 | lifeskim:mentions | umls-concept:C0123711 | lld:lifeskim |
| pubmed-article:1851113 | lifeskim:mentions | umls-concept:C0728940 | lld:lifeskim |
| pubmed-article:1851113 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
| pubmed-article:1851113 | lifeskim:mentions | umls-concept:C0021666 | lld:lifeskim |
| pubmed-article:1851113 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:1851113 | pubmed:dateCreated | 1991-6-10 | lld:pubmed |
| pubmed-article:1851113 | pubmed:abstractText | The levels of insulin-like growth factor II/mannose-6-phosphate (IGF-II/Man-6-P) receptor and the insulin-like growth factor I (IGF-I) receptor were measured in the intestinal epithelium after 50% resection of the small intestine. Controls were either pair-fed to match the reduced food intake of the resected group or fed ad libitum. [125I]IGF-II binding was transiently increased 2-fold in the distal segment of the small intestine 3 days after resection compared with the pair-fed control. Receptor levels increased from 2.60 nmol/mg protein (pair-fed) to 4.63 nmol/mg protein (resected; p less than 0.001) with no significant change in affinity of IGF-II binding (Kd = 11.2 vs. 9.8 nmol/l). The increase in IGF-II/Man-6-P receptors coincided with increased activity of thymidine kinase in the distal intestinal segment after the resection. [125I]IGF-I binding remained unchanged after the resection. However, the decreased food intake of the pair-fed and resected groups caused a 2-fold increase in the amount of IGF-I receptors (0.18 nmol/mg protein; p less than 0.001) compared with the control fed ad libitum (0.08 nmol/mg protein). IGF-II/Man-6-P receptors were only moderately increased during restricted food intake (2.60 vs. 1.78 nmol/mg protein; p less than 0.005). These results suggest that the IGF-II/Man-6-P receptor may play a role in the adaptive regenerative response of the intestinal epithelium. | lld:pubmed |
| pubmed-article:1851113 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1851113 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1851113 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1851113 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1851113 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1851113 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1851113 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1851113 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1851113 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1851113 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1851113 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1851113 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:1851113 | pubmed:issn | 0303-7207 | lld:pubmed |
| pubmed-article:1851113 | pubmed:author | pubmed-author:LaburtheMM | lld:pubmed |
| pubmed-article:1851113 | pubmed:author | pubmed-author:MorinCC | lld:pubmed |
| pubmed-article:1851113 | pubmed:author | pubmed-author:GammeltoftSS | lld:pubmed |
| pubmed-article:1851113 | pubmed:author | pubmed-author:BourqueMM | lld:pubmed |
| pubmed-article:1851113 | pubmed:author | pubmed-author:Rouyer-Fessar... | lld:pubmed |
| pubmed-article:1851113 | pubmed:author | pubmed-author:GreyVV | lld:pubmed |
| pubmed-article:1851113 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1851113 | pubmed:volume | 75 | lld:pubmed |
| pubmed-article:1851113 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1851113 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1851113 | pubmed:pagination | 221-7 | lld:pubmed |
| pubmed-article:1851113 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:1851113 | pubmed:meshHeading | pubmed-meshheading:1851113-... | lld:pubmed |
| pubmed-article:1851113 | pubmed:meshHeading | pubmed-meshheading:1851113-... | lld:pubmed |
| pubmed-article:1851113 | pubmed:meshHeading | pubmed-meshheading:1851113-... | lld:pubmed |
| pubmed-article:1851113 | pubmed:meshHeading | pubmed-meshheading:1851113-... | lld:pubmed |
| pubmed-article:1851113 | pubmed:meshHeading | pubmed-meshheading:1851113-... | lld:pubmed |
| pubmed-article:1851113 | pubmed:meshHeading | pubmed-meshheading:1851113-... | lld:pubmed |
| pubmed-article:1851113 | pubmed:meshHeading | pubmed-meshheading:1851113-... | lld:pubmed |
| pubmed-article:1851113 | pubmed:meshHeading | pubmed-meshheading:1851113-... | lld:pubmed |
| pubmed-article:1851113 | pubmed:meshHeading | pubmed-meshheading:1851113-... | lld:pubmed |
| pubmed-article:1851113 | pubmed:meshHeading | pubmed-meshheading:1851113-... | lld:pubmed |
| pubmed-article:1851113 | pubmed:meshHeading | pubmed-meshheading:1851113-... | lld:pubmed |
| pubmed-article:1851113 | pubmed:meshHeading | pubmed-meshheading:1851113-... | lld:pubmed |
| pubmed-article:1851113 | pubmed:meshHeading | pubmed-meshheading:1851113-... | lld:pubmed |
| pubmed-article:1851113 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1851113 | pubmed:articleTitle | Insulin-like growth factor II/mannose-6-phosphate receptors are transiently increased in the rat distal intestinal epithelium after resection. | lld:pubmed |
| pubmed-article:1851113 | pubmed:affiliation | Centre de Recherche, Hôpital Sainte-Justine, Montreal, Quebec, Canada. | lld:pubmed |
| pubmed-article:1851113 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1851113 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
