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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1991-5-31
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pubmed:abstractText |
Seven nalidixic acid-resistant clinical isolates of Escherichia coli were shown to carry resistance mutations in their gyrase A proteins. Six had serine-83 to leucine or tryptophan changes; the seventh had an aspartate-87 to valine substitution. The frequent occurrence of a mutation at serine-83 implies a key role for this residue in quinolone action.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1850972-14276097,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1850972-153529,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1850972-186775,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1850972-2155395,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1850972-2160946,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1850972-2168148,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1850972-2546585,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1850972-2548439,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1850972-2555327,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1850972-2574005,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1850972-2655532,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1850972-271968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1850972-2828631,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1850972-2830458,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1850972-2838070,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1850972-2987847,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1850972-2992360,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1850972-3000292,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1850972-3020376,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1850972-3031051,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1850972-337300,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1850972-347446,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1850972-4895844
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0066-4804
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
35
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
387-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:1850972-Amino Acid Sequence,
pubmed-meshheading:1850972-Anti-Infective Agents,
pubmed-meshheading:1850972-Base Sequence,
pubmed-meshheading:1850972-DNA, Bacterial,
pubmed-meshheading:1850972-DNA Topoisomerases, Type II,
pubmed-meshheading:1850972-Drug Resistance, Microbial,
pubmed-meshheading:1850972-Escherichia coli,
pubmed-meshheading:1850972-Humans,
pubmed-meshheading:1850972-Molecular Sequence Data,
pubmed-meshheading:1850972-Molecular Weight,
pubmed-meshheading:1850972-Nalidixic Acid,
pubmed-meshheading:1850972-Polymerase Chain Reaction,
pubmed-meshheading:1850972-Sulfur Radioisotopes
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pubmed:year |
1991
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pubmed:articleTitle |
4-Quinolone resistance mutations in the DNA gyrase of Escherichia coli clinical isolates identified by using the polymerase chain reaction.
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pubmed:affiliation |
Department of Cellular and Molecular Sciences, St. George's Hospital Medical School, London, United Kingdom.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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