Source:http://linkedlifedata.com/resource/pubmed/id/18509069
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2008-8-13
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| pubmed:abstractText |
These studies investigated whether a single electrical stimulus over the thoracic spine activates corticospinal axons projecting to human leg muscles. Transcranial magnetic stimulation of the motor cortex and electrical stimulation over the thoracic spine were paired at seven interstimulus intervals, and surface electromyographic responses were recorded from rectus femoris, tibialis anterior, and soleus. The interstimulus intervals (ISIs) were set so that the first descending volley evoked by cortical stimulation had not arrived at (positive ISIs), was at the same level as (0 ISI) or had passed (negative ISIs) the site of activation of descending axons by the thoracic stimulation at the moment of its delivery. Compared with the responses to motor cortical stimulation alone, responses to paired stimuli were larger at negative ISIs but reduced at positive ISIs in all three leg muscles. This depression of responses at positive ISIs is consistent with an occlusive interaction in which an antidromic volley evoked by the thoracic stimulation collides with descending volleys evoked by cortical stimulation. The cortical and spinal stimuli activate some of the same corticospinal axons. Thus it is possible to examine the excitability of lower limb motoneuron pools to corticospinal inputs without the confounding effects of changes occurring within the motor cortex.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:status |
MEDLINE
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| pubmed:month |
Aug
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| pubmed:issn |
0022-3077
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
100
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1080-6
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| pubmed:meshHeading |
pubmed-meshheading:18509069-Adult,
pubmed-meshheading:18509069-Analysis of Variance,
pubmed-meshheading:18509069-Blood Pressure,
pubmed-meshheading:18509069-Electric Stimulation,
pubmed-meshheading:18509069-Electromyography,
pubmed-meshheading:18509069-Evoked Potentials, Motor,
pubmed-meshheading:18509069-Heart Rate,
pubmed-meshheading:18509069-Humans,
pubmed-meshheading:18509069-Leg,
pubmed-meshheading:18509069-Motor Cortex,
pubmed-meshheading:18509069-Muscle, Skeletal,
pubmed-meshheading:18509069-Muscle Contraction,
pubmed-meshheading:18509069-Pyramidal Tracts,
pubmed-meshheading:18509069-Reaction Time,
pubmed-meshheading:18509069-Spinal Cord,
pubmed-meshheading:18509069-Thorax,
pubmed-meshheading:18509069-Time Factors,
pubmed-meshheading:18509069-Transcranial Magnetic Stimulation
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| pubmed:year |
2008
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| pubmed:articleTitle |
Noninvasive stimulation of human corticospinal axons innervating leg muscles.
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| pubmed:affiliation |
Prince of Wales Medical Research Institute, Barker Street, Randwick, Sydney, NSW 2031, Australia.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|