Linked Life Data

18508721

Source:http://linkedlifedata.com/resource/pubmed/id/18508721

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2008-5-29
pubmed:abstractText
Focal adhesion associated protein (FAAP), encoded by murine D10Wsu52e gene, is highly homologous to human HSPC117, which interacts with vinculin and talin. HeLa cells transfected with FAAP exhibited normal adhesion incorporation but showed impaired cell spreading, and restrained focal adhesion translocation. Moreover, FAAP facilitated vinculin-paxillin association, decreased interaction of paxillin-focal adhesion kinase and inhibited the phosphorylation of extracellular signal-regulated kinase. Together, these results suggest that FAAP, by virtue of modulating interaction of adhesion molecules, regulates cell adhesion dynamics.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1093-4715
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
7123-31
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
FAAP, a novel murine protein, is involved in cell adhesion through regulating vinculin-paxillin association.
pubmed:affiliation
The Key Laboratory of Cell Proliferation and Differentiation of Ministry of Education, The Department of Cell Biology and Genetics, College of Life Sciences, Peking University, Beijing 100871, PR China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't